Proc Natl Acad Sci U S A
September 2024
The efficacy of hydrogel materials used in biomedical applications is dependent on polymer network topology and the structure of water-laden pore space. Hydrogel microstructure can be tuned by adjusting synthesis parameters such as macromer molar mass and concentration. Moreover, hydrogels beyond dilute conditions are needed to produce mechanically robust and dense networks for tissue engineering and/or drug delivery systems.
View Article and Find Full Text PDFPoly(ethylene glycol) (PEG)-based nanogels are attractive for biomedical applications due to their biocompatibility, versatile end group chemistry, and ability to sterically shield encapsulated drug molecules. The characteristics of a hydrogel network govern the encapsulation and efficient delivery of drug molecules for a target application. A molecular-level description of network topology can complement experimental investigations to understand its effects on the structural properties of these nanogels.
View Article and Find Full Text PDFIonic-functionalized microporous materials are attractive for energy-efficient gas adsorption and separation processes and have shown promising results in gas mixtures at pressure ranges and compositions that are relevant for industrial applications. In this work, we studied the influence of different counterions (Li, Na, K, Rb, and Mg) on the porosity, carbon dioxide (CO) gas adsorption, and selectivity in ionic-functionalized PIM-1 (IonomIMs), a polymer belonging to the class of linear and amorphous microporous polymers known as polymers of intrinsic microporosity (PIMs). It was found that an increase in the concentration of ionic groups led to a decrease in the free volume, resulting in a less porous polymer framework, and Mg-functionalized IonomIMs exhibited a relatively larger porosity compared to other IonomIMs.
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