Alterations in Bone Turnover during Chemotherapy in Children with Acute Lymphoblastic Leukemia.

Disturbances of bone metabolism frequently occur in children with acute lymphoblastic leukemia (ALL), leading to increased risk of osteopenia and osteoporosis at diagnosis, during and after completion of chemotherapy. The present study was performed to evaluate alteration in bone mineral metabolism in children with ALL during chemotherapy. Fifty newly diagnosed patients with ALL in the age group of 2 to 14 years were included.