Publications by authors named "Shalini Batheja"
ACS Infect Dis
February 2024
Article Synopsis
- Gram-negative bacterial infections are challenging to treat due to antibiotic resistance linked to their protective membranes, with polymicrobial infections requiring higher antibiotic doses.
- Antibiotic adjuvants can enhance the effectiveness of existing antibiotics, but their potential toxicity remains a concern for clinical use.
- The study identified xanthone-derived compounds that work synergistically with neomycin to increase its efficacy, improve membrane penetration, and show potential in treating both monomicrobial and polymicrobial infections without harming mammalian cells.
