Publications by authors named "Shalana B L O'Brien"

Mucinous (colloid) adenocarcinomas (MAs) are a rare histological subtype of tumors defined by extracellular mucin comprising more than 50% of the tumor. These tumors are on a continuum of mucin-producing malignancies with signet ring cell adenocarcinomas (SRCCs), which instead produce intracellular mucin. Mucin-containing cancers occur primarily in the stomach and colon, where for SRCCs, outcomes are relatively worse in the proximal stomach and the rectum.

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Signet ring cell adenocarcinomas (SRCCs) are a rare and aggressive histological subtype of adenocarcinomas typically with poor prognosis usually secondary to late stage at detection. In the small bowel, they constitute only 1% of all malignancies. In the last decade, there have been multiple case reports and small case series that have identified SRCCs, typically in the ileum, in patients with Crohn's disease.

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Article Synopsis
  • Signet ring cell adenocarcinomas (SRCCs) are a rare cancer subtype mainly found in the stomach and colon, and they generally have a worse prognosis than typical adenocarcinomas, especially in patients over 50.
  • SRCCs in younger patients mainly affect the lower part of the stomach, while colorectal SRCCs have particularly poor outcomes across all ages, especially in younger patients.
  • This study analyzes data from the SEER database to better understand how tumor location, age, and stage influence outcomes for SRCCs compared to conventional adenocarcinomas.
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Undifferentiated carcinomas are rare cancers that lack differentiation, such that they cannot be classified into any conventional histological subtype. These cancers are uniquely codified and are contrasted to carcinomas with an ascertained histology that are grade classified as poorly differentiated, undifferentiated, or anaplastic. Given their rarity, there are no standardized overviews of undifferentiated carcinomas in the literature, and it is unknown if their classification indicates a unique prognosis profile.

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