Bioactive Potential of Chitosan-Oleic Acid Nanoparticles Loaded with Lemon Peel Essential Oil for Topical Treatment of Vulvovaginal Candidiasis.

The rising incidence of vulvovaginal candidiasis (VVC) has been leading to the development of alternative antifungal therapies. This study aimed to develop a topical chitosan-oleic acid nanoparticle (CH-OA-NP) cream loaded with lemon peel essential oil (LPEO) for VVC treatment. The characterization of the optimal nanoparticle formulation (F4: 10 g/L CH, 2:1 OA/LPEO ratio) showed high encapsulation efficiency, stability, and controlled release.

Quantitative and qualitative analysis of bioaerosols emissions from the domestic eastern wastewater treatment plant, Alexandria, Egypt.

Bioaerosol studies showed that wastewater treatment plants (WWTPs) are a significant source of bioaerosol emissions. In this study, 170 samples of total bacteria, total coliform, and total fungi were collected from 10 sites within a domestic WWTP, Alexandria, Egypt, using the sedimentation technique. According to the Index of Microbial Air Contamination (IMA) classes, the total bacteria range was 108-5120 CFU/dm/hour, and all samples were classified as "very poor" except one sample of an office, which was classified as "poor.

Hyaluronate functionalized Span-Labrasol nanovesicular transdermal therapeutic system of ferulic acid targeting diabetic nephropathy.

Diabetic kidney disease, known as diabetic nephropathy (DN), is a widespread severe diabetes complication leading to kidney failure. Due to the lack of efficacious therapies, this study endeavors to enhance DN therapeutic effectiveness of ferulic acid (FRA), a natural phenolic with poor oral bioavailability, by developing a transdermal kidney-targeted spanlastic formulation. Spanlastics (SP) nanovesicles were prepared using Span 60 and Labrasol or Brij35 as edge activators (EA).

Impact of specialized renal technologists on optimizing delivery of continuous kidney replacement therapy in critical care areas a retrospective study.

Background: Continuous renal replacement therapy (CKRT) is delivered to some of the most critically ill patients in hospitals. This therapy is expensive and requires coordination of multidisciplinary teams to ensure the prescribed dose is delivered. With increased demands on the critical care nursing staff and increased complexities of patients admitted to critical care units, we evaluated the role of specialized renal technologists in ensuring the prescribed dose is delivered.

Chitosan tamarind-based nanoparticles as a promising approach for topical application of curcumin intended for burn healing: and study.

One of the most prevalent worldwide problems that affect all ages and genders is skin burn. The goal of our study was to assess the ability of curcumin nanoparticles to cure a rat burn model. Three formulations were selected after several tests were performed including investigation of encapsulation efficiency, particle size and zeta potential measurements.

Assessing vulnerability of densely populated areas to air pollution using Sentinel-5P imageries: a case study of the Nile Delta, Egypt.

Air pollution represents one of the major environmental stressors with serious implications on human health and ecosystem health. Recently remote sensing imageries; as an alternative cost and time-effective method compared with regular monitoring techniques, were used for provision of appropriate data concerning air quality over large areas. In this context, Sentinel-5P satellite provides high-resolution images of atmospheric pollutants including nitrogen dioxide, ozone, carbon monoxide (CO) and particulate matter (PM).

Simultaneous voltammetric sensing of Zn, Cd, and Pb using an electrodeposited Bi-Sb nanocomposite modified carbon paste electrode.

A sensor for detecting Zn, Cd, and Pb ions simultaneously based on the square wave anodic stripping response at a bismuth antimony (Bi-Sb) nanocomposite electrode was developed. The electrode was prepared by electrodepositing bismuth and antimony on the surface of a carbon-paste electrode (CPE) while also reducing the analyte metal ions. The structure and performance of the Bi-Sb/CPE electrode were studied using scanning electron microscopy, X-ray diffraction, electrochemical impedance spectroscopy, and cyclic voltammetry.

Optimization of folic acid Span 60-organogel to enhance its and photoprotection: a comparative study.

The acute effects of UV sunlight exposure were inflammation, erythema, and swelling. The present work aims to formulate a novel organogel preparation that can achieve efficient topical folic acid (FA) delivery to cure inflammation from acute exposure to UV sunlight. The organogels were prepared by direct melting and stirring on a magnetic stirrer.

Biological activities and antioxidant potential of different biosynthesized nanoparticles of Moringa oleifera.

The science of nanotechnology is expanding daily and has the potential to benefit people. Moringa oleifera is an abundant source of phenolic compounds, which are bioactive substances. It is recognised as a necessary plant because of its medicinal potential and a wide variety of health benefits.

Role of multiparametric magnetic resonance imaging in the diagnosis and staging of urinary bladder cancer.

Objectives: To assess the role of multiparametric magnetic resonance imaging (mp-MRI) in the diagnosis and staging of urinary bladder cancer (BC).

Materials And Methods: Fifty patients diagnosed with bladder masses underwent mp-MRI study. The results of 3 image sets were analyzed and compared with the histopathological results as a reference standard: T2-weighted image (T2WI) plus dynamic contrast-enhanced (DCE), T2WI plus diffusion-weighted images (DWI), and mp-MRI, including T2WI plus DWI and DCE.

Enhancement of plant growth regulators production from microalgae cultivated in treated sewage wastewater (TSW).

The aim of this work is to develop an efficient method for detection and evaluation of the plant growth regulators produced from cyanobacteria species (Anabaena oryzae and Nostoc muscorum) cultivated on BG11, and Chlorophyta alga (Chlorella vulgaris) cultivated on BG11 in addition to the cultivation of these strains on treated sewage wastewater (TSW) combined with control media (BG11 and BG11) at different concentrations (100, 75 and 50%). Bioassays were performed on Wheat coleoptile length and Cucumber cotyledons fresh weight for indole acetic acid (IAA) and Benzyl adenine (BA) detection. In addition, application experiments of IAA and BA presence in algal extract were applied on tomato plantlets and soybean callus.

Vitamin D: an essential adjuvant therapeutic agent in breast cancer.

Low serum levels of vitamin D have been reported as a risk factor for breast cancer. This narrative review provides an update on the impact of vitamin D on hormone receptors, notably estrogen receptor subunits, and gives insights on possible therapeutic interventions to overcome breast cancer. In addition, evidence that supports the beneficial use of vitamin D as adjuvant treatment of breast cancer is summarized.

Impact of forced diuresis on retropulsion of disintegrated ureteral calculi during semi-rigid ureteroscopy: a double-blind randomized-controlled study.

The objective of this study is to assess the safety and efficacy of forced diuresis as an antiretropulsion strategy during the pneumatic disintegration of solitary lower ureteric stones with semi-rigid ureteroscopy (URS). A prospective randomized double-blind study was carried out from March 2019 to June 2021 for patients presented with unilateral solitary radiopaque lower ureteric stones ≤ 20 mm. Patients were randomized for URS into two groups, according to the use of forced diuresis using furosemide 1 mg/kg (GII) or not (GI).

Utilizing deep learning models in CSI-based human activity recognition.

In recent years, channel state information (CSI) in WiFi 802.11n has been increasingly used to collect data pertaining to human activity. Such raw data are then used to enhance human activity recognition.

Assess the safety and effectiveness of a novel approach during transurethral pneumatic cystolithotripsy in large urinary bladder stone: quasi-clinical trial.

To assess the safety and efficacy of using continuous irrigation-modified hysteroscopy during transurethral pneumatic cystolithotripsy for large bladder calculi. A prospective study was carried out from May 2016 until March 2020. All patients with solitary or multiple bladder stones > 2.

3-Alkenyl-2-oxindoles: Synthesis, antiproliferative and antiviral properties against SARS-CoV-2.

Sets of 3-alkenyl-2-oxindoles (6,10,13) were synthesized in a facile synthetic pathway through acid dehydration (EtOH/HCl) of the corresponding 3-hydroxy-2-oxoindolines (5,9,12). Single crystal (10a,c) and powder (12a,26f) X-ray studies supported the structures. Compounds 6c and 10b are the most effective agents synthesized (about 3.

Evaluation of the Expression of HER2 and c-KIT Proteins as Prognostic Markers in Superficial Bladder Urothelial Carcinoma.

Background: The roles of c-KIT and HER2 protein expression in bladder cancer are still debated, and the prognostic value of these proteins as markers of tumor progression is inconclusive.

Objective: To assess the impact of HER2 and c-KIT protein expressions in the progression of non-muscle-invasive bladder cancer.

Methods: All patients undergoing transurethral resection of bladder tumors for non-muscle-invasive urothelial carcinoma, with standard regimen of BCG, between January 2017 and November 2019, were evaluated pathologically and immunohistochemically for HER1 and c-KIT proteins in urothelial carcinoma cells.

Enhancement of active ingredients and biological activities of biomass cultivated under modified BG-11 medium composition.

The current work aims to investigate the effect of abiotic stresses (nitrogen (N) and sulfur (S) [0.0 g/l, 1.5 g/l, 3 g/l, 6 g/l, and 12 g/l N and 0.

Ultrasound Diagnosis and Active Ureteroscopy for Obstructive Ureteral Calculi During Pregnancy: Multicenter Experience.

To evaluate the safety and efficacy of ultrasound (US) and primary ureteroscopy (URS) in the management of symptomatic obstructive ureteric stones during pregnancy. A prospective multicenter study was performed between June 2013 and December 2019, including all consecutive pregnant patients admitted to three urology centers with intractable renal colic with obstructed ureter secondary to obstructive ureteral calculi. Color Doppler ultrasound was used to evaluate renal Resistive Index (RI) and ureter jet.

The CO photoconversion over reduced graphene oxide based on Ag/TiO photocatalyst in an advanced meso-scale continuous-flow photochemical reactor.

This study aims at examining the use of an advanced meso-scale continuous-flow photochemical reactor for the photocatalytic conversion of CO with water into fuel over TiO (P25), Ag/TiO, and Ag/TiO/RGO catalysts. The silver loaded photocatalysts were prepared by one-step process via hydrothermal method. The prepared photocatalysts were characterized by various characterization techniques in order to identify the morphological, chemical, physical, and optical properties.

Evaluation of antioxidant and anticancer activity of crude extract and different fractions of Chlorella vulgaris axenic culture grown under various concentrations of copper ions.

Background: Chlorella vulgaris is a microalga potentially used for pharmaceutical, animal feed, food supplement, aquaculture and cosmetics. The current study aims to study the antioxidant and prooxidant effect of Chlorella vulgaris cultivated under various conc. of copper ions.

Diagnostic accuracy of the placenta accreta index for placenta accreta spectrum: A prospective study.

Objective: To evaluate the role of the placenta accreta index (PAI) score in predicting placenta accreta spectrum (PAS).

Methods: In this prospective study, the PAI was applied to 100 third-trimester pregnant women with at least one previous cesarean delivery (CS) and anterior low-lying placenta or placenta previa. PAI score was calculated based on placental location, number of CS, abnormal placental lacunae, sagittal smallest myometrial thickness (SSMT), and bridging vessels.

Synthesis of some tropane-based compounds targeting colon cancer.

In continuation of a previous work concerned with the anticancer activity of some 8-alkyl-2,4-bisarylidene-8-nortropan-3-ones, this work focuses on further modification to the tropane/pyran fused skeleton aiming to obtain improved anticancer activity. Reaction of 8-alkyl-2,4-bisarylidene-8-nortropan-3-ones with malononitrile under basic conditions afforded tropane/pyran hybrids and tropane/pyridine hybrids , . X-ray crystallography for compounds and as representative examples confirmed their structures.

Synthesis and molecular modeling studies of cholinesterase inhibitor dispiro[indoline-3,2'-pyrrolidine-3',3''-pyrrolidines].

A set of dispiro[indoline-3,2'-pyrrolidine-3',3''-pyrrolidines] 8a-l was regioselectively synthesized utilizing multi-component azomethine cycloaddition reaction of 3-(arylmethylidene)pyrrolidine-2,5-diones 5a-e, isatins 6a-c and sarcosine 7. Single crystal X-ray studies of 8c add conclusive support for the structure. Compounds 8e and 8g reveal cholinesterase inhibitory properties with promising efficacy against both AChE and BChE and were found to be more selective towards AChE than BChE as indicted by the selectivity index like Donepezil (a clinically used cholinesterase inhibitory drug).