Publications by authors named "Shakthiraju R G"
Article Synopsis
- Genetic factors significantly influence how long individuals live, and this study focuses on identifying these genetic variants in the Indian population by comparing individuals aged 85+ (long living individuals, LLIs) with younger controls aged 18-49.
- The research utilized a custom chip for genetic data, revealing 9 variants linked to longevity, with certain alleles associated with positive traits like slower heart rate and lower risks for various disorders being more common in LLIs, while other risky alleles were less frequent.
- The study also found that genes related to oxidative stress, DNA repair, and metabolism play important roles in healthy aging and longevity, confirming the genetic basis for these traits in the population.
Coronavirus outbreak in December 2019 (COVID-19) is an emerging viral disease that poses major menace to Humans and it's a crucial need to find the possible treatment strategies. Spike protein (S2), a envelop glycoprotein aids viral entry into the host cells that corresponds to immunogenic ACE2 receptor binding and represents a potential antiviral drug target. Several drugs such as antimalarial, antibiotic, anti-inflammatory and HIV-protease inhibitors are currently undergoing treatment as clinical studies to test the efficacy and safety of COVID-19.
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