Sodium-dependent phosphate transporter NaPi2b as a potential predictive marker for targeted therapy of ovarian cancer.

The high mortality rate from ovarian cancer is due to the asymptomatic nature of the course of the disease, which leads to the diagnosis of ovarian cancer in later stages. The sodium-dependent phosphate transporter NaPi2b encoded by gene is expressed in 80-90% of epithelial ovarian cancers and used as a target for therapeutic antibodies XMT-1536, and XMT-1592, which are derived from MX35 antibodies and used in clinical trials for the treatment of ovarian and lung cancers. In this work, we aimed to evaluate NaPi2b as a molecular marker for diagnostics and predicting the course and outcome of ovarian cancer disease.

[Contemporary state of work conditions and occupational morbidity of workers engaged into rubber, mechanical rubber and tire industries].

Based on analysis of materials provided by occupational safety department PC "UZEMiK" and JSC "Kauchuk", the authors evaluate contemporary work conditions and occupational morbidity in workers engaged into rubber, mechanical rubber and tyre industries.

[The morbidity with temporary disability among workers of petrochemical industry].

The article deals with the data on morbidity with temporary disability among workers producing rubber and mechanical rubber articles in petrochemical industry. The leading place in the structure of morbidity is taken by the diseases of nervous and cardiovascular systems, liver, gastrointestinal tract, respiratory system and thyroid gland.

[Health state of workers in petrochemical enterprise].

The article covers evaluation of health state in workers of main petrochemical workshops. Leading place in structure of transitory disablement morbidity in workers is occupied by cardiovascular and nervous disorders, diseases of liver, gastrointestinal tract and respiratory system.

[Acid and osmotic resistance of RBC in workers engaged in rubber and technical rubber production in petrochemical industry].

The authors present results obtained in a study of how rubber and technical rubber products influence acid and osmotic resistance of RBC in workers engaged into petrochemical industry. Findings are that the rubber and technical rubber products sensitize the RBC to osmotic and acidic lysis.

[Nervous system function in persons receiving irradiation at different dose ranges during the cleanup after the accident at the Chernobyl Atomic Electric Power Station].

The paper is concerned with the results of neurological examination of 113 patients who developed acute radiation sickness of various degrees of severity during the elimination of the effects of the accident at the Chernobyl Nuclear Power Station. A clinical picture of neurological disorders at different periods of ARS was described. CNS specific and nonspecific lesions were defined.

[The vitamin D allowance of premature infants and their phosphorus-calcium metabolic status with different types of feeding and rickets prevention].

The content of 25-hydroxycholecalciferol, calcium and phosphorus in blood serum was measured in 80 premature infants aged 12 to 120 days depending on the type of feeding and rickets prevention. Administration of vitamin D in a dose of 400 IU and increase of calcium consumption up to 110-120 mg and of phosphorus to 45-57 mg per kg body weight at the expense of calcinated cottage introduction into the diet provide for the optimal levels of 25-hydroxycholecalciferol and calcium in the blood of these children. Administration of calcium and phosphorus to children receiving breast feeding in doses of 80-90 and 33-37 mg/kg, respectively, is not sufficient for the maintenance of calcium homeostasis and endogenous supply with vitamin D even if the latter is given prophylactically.