Unique gene expression profile based on pathologic response in epithelial ovarian cancer.

Purpose: We investigated whether tumor tissue obtained at diagnosis expresses a specific gene profile that is predictive of findings at second-look surgery in patients with epithelial ovarian cancer (EOC).

Patients And Methods: Tumor tissue obtained at the time of diagnosis was profiled with oligonucleotide microarrays. Class prediction analysis was performed in a training set of 24 patients who had undergone a second-look procedure.

Gene signatures of progression and metastasis in renal cell cancer.

Purpose: To address the progression, metastasis, and clinical heterogeneity of renal cell cancer (RCC).

Experimental Design: Transcriptional profiling with oligonucleotide microarrays (22,283 genes) was done on 49 RCC tumors, 20 non-RCC renal tumors, and 23 normal kidney samples. Samples were clustered based on gene expression profiles and specific gene sets for each renal tumor type were identified.