Publications by authors named "Shakila Afroz Taleb"
Article Synopsis
- Autophagy is a vital cell process that maintains balance by recycling cell components, and it has a significant but complex role in cancer stem cells (CSCs) and stem cell therapy.
- The study highlights the molecular mechanisms that regulate autophagy in the context of CSCs, emphasizing its dual role in both removing and maintaining these cells, alongside the challenges in understanding the related signaling pathways.
- Targeting autophagy with synthetic and natural compounds shows potential in improving therapies for cancer and regenerative medicine, but there are hurdles like treatment resistance that need to be overcome for effective applications.
Background & Aims: Cystic fibrosis-related liver disease (CFLD) is a chronic cholangiopathy that increases morbidity and mortality in patients with CF. Current treatments are unsatisfactory, and incomplete understanding of CFLD pathogenesis hampers therapeutic development. We have previously shown that mouse CF cholangiocytes respond to lipopolysaccharide with excessive inflammation.
View Article and Find Full Text PDFBackground And Aims: Cholangiopathies are an important cause of morbidity and mortality. Their pathogenesis and treatment remain unclear in part because of the lack of disease models relevant to humans. Three-dimensional biliary organoids hold great promise; however, the inaccessibility of their apical pole and the presence of extracellular matrix (ECM) limits their application.
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