Using an Artificial Neural Network to Predict Coronary Microvascular Obstruction (No-Reflow Phenomenon) during Percutaneous Coronary Interventions in Patients with Myocardial Infarction.

Unlabelled: was to develop, evaluate, and validate an artificial neural network to predict coronary microvascular obstruction (CMVO) during percutaneous coronary interventions (PCI) in patients with myocardial infarctions (MI) based on the parameters, which are routinely available in an operating room when choosing a surgical approach.

Materials And Methods: 5621 patients with MI and emergency PCI were retrospectively selected from the database of the City Clinical Hospital No.13 (Nizhny Novgorod, Russia); among them, there were 3935 men (70%) and 1686 women (30%), their mean age was 61.

CT26 murine colon carcinoma expressing the red fluorescent protein KillerRed as a highly immunogenic tumor model.

The development of tumor therapies based on the activation of antitumor immunity requires tumor models that are highly immunogenic. The immunologic response to fluorescent proteins, green fluorescent protein (GFP), or enhanced GFP (EGFP) was demonstrated in different cancer models. However, for live animal imaging, red and far-red fluorescent proteins are preferable, but their immunogenicity has not been studied.

Photobleaching and phototoxicity of KillerRed in tumor spheroids induced by continuous wave and pulsed laser illumination.

The purpose of this study was to evaluate photobleaching of the genetically encoded photosensitizer KillerRed in tumor spheroids upon pulsed and continuous wave (CW) laser irradiation and to analyze the mechanisms of cancer cell death after the treatment. We observed the light-dose dependent mechanism of KillerRed photobleaching over a wide range of fluence rates. Loss of fluorescence was limited to 80% at light doses of 150 J/cm(2) and more.

[Revascularization of the myocardium and kidneys in patients with combined atherosclerotic lesions of coronary and renal arteries].

The study included a total of 109 patients presenting with combined atherosclerotic lesions of coronary and renal arteries. Depending on severity of angina pectoris, the patients were subdivided into two groups. Group One consisted of patients subjected to revascularization of the myocardium and kidneys, and Group Two comprised those with a dominating clinical picture of vasorenal hypertension syndrome and undergoing surgery on renal arteries alone.

Flavoprotein miniSOG as a genetically encoded photosensitizer for cancer cells.

Background: Genetically encoded photosensitizers are a promising optogenetic instrument for light-induced production of reactive oxygen species in desired locations within cells in vitro or whole body in vivo. Only two such photosensitizers are currently known, GFP-like protein KillerRed and FMN-binding protein miniSOG. In this work we studied phototoxic effects of miniSOG in cancer cells.

[Optical introscopy is a new diagnostic technique in reproductive medicine].

The WHO classification's concept "infertility of unclear genesis" is due to a number of circumstances. On the one hand, this is a preponderance of the subtle forms of diseases, which are a cause of female infertility, including the subclinical forms of small pelvic inflammatory diseases (SPID). On the other hand, this is an imperfection of existing diagnostic methods.

[Successful endovascular treatment for a false aneurysm of the hepatic artery using a stent-graft (a remote follow-up case report)].

Presented herein is a clinical case report concerning a female patient diagnosed with a pseudoaneurysm of the hepatic artery, chronic panel eatitis, and a pancreatic cyst. The woman was subjected to intravascular treatment consisting in reconstruction of the hepatic artery at the site of the origin of the aneurysmal neck with a stent graft.

[Optic coherent tomography: a new high-resolution technology of visualization of tissue structures. Communication II. Optical images of benign and malignant entities].

This is the second communication of a series of publications on Russian studies in the field of optical coherent tomography (OCT), the newest noninvasive highly resolving technology of visualization of the structure of biological tissues. By using the investing tissues as an example, this paper demonstrates the universal types of changes in their optical properties. Optimal images permit differentiate benign and malignant processes with a high degree of diagnostic accuracy.

[Optic coherent tomography: a new high-resolution technology of visualization of tissue structures. Part 1. Principle of the technique. Objects of OCT applications and technical decisions for their study].

The authors present a series of three papers dedicated to studies made in Russia in the field of optic coherent tomography (OCT), the latest noninvasive high-resolution technology of visualization of the structure of biological tissues. A group of medical specialists of different disciplines has been examined over 2,000 patients for 8 years of the use of an original class of the Russian OCT devices developed at the Institute of Applied Physics, Russian Academy of Sciences, and awarded a RF State Prize in the field of science and technology in 1999. The first paper discusses the basic aspects of OCT, the objects of study, and technical decisions for the clinical application of the technique.

[Ultrasonic diagnosis of subpleural parietal formations of the lung].

The article generalizes experiences with ultrasonic scanning of the chest in patients with subpleural parietal formations of the lungs of inflammatory and tumorous etiology. The technique of the investigation and criteria of the assessment of the pathological focus are described. The normal echoscopic picture of the chest was determined.

Safety and efficacy of interventional occlusion of patent ductus arteriosus with detachable coils: a multicentre experience.

Unlabelled: In order to define the safety and efficacy of Cook detachable coils for interventional closure of patent ductus arteriosus, we performed a retrospective analysis of all patients who underwent cardiac catheterization in seven centres for intended interventional occlusion of patent arterial duct. From January 1995 until March 1998, cardiac catheterization for intended interventional occlusion of patent arterial duct was performed in 317 consecutive children. Successful placement of at least one coil was achieved in 282 children (89%).

[Arterial factors in the mechanism of penile erection].

Hemodynamic study of the penis in diagnosis of erectile impotence is thought essential because many investigators have obtained evidence for involvement of vascular affections in the mechanisms of somatogenic erectile disturbances in 70-80% of the cases. The authors have assessed arterial and venous phases of penile hemodynamics in healthy males at rest and erection (28 subjects aged 24-56) and in 37 patients with functional sex disturbances aged 21-43. It was found that erection is maintained not only in participation of deep penile arteries, but also dorsal ones.

[The drug treatment of cardiogenic shock--our experience].

For the period 1970-1989 in the intensive care unit of the National Center for Cardiovascular Diseases, 178 patients with cardiogenic shock were treated and died. These patients were studied retrospectively. In all patients an acute myocardial infarction was proved clinically and post mortem.

[The diagnostic potentials of spatial velocity ECG in assessing the changes in ventricular depolarization].

The study includes 702 patients (with left ventricular load, myocardial infarction and bundle branch block) and 130 healthy persons. To all these a spatial velocity EKG was made (SVEKG) as well as corrected orthogonal electro- and vectorcardiogram according to Frank, spatial ECG and standard EKG in 12 leads. The indices of the spatial velocity ECG were compared with those of the other methods on the basis of the criteria sensitivity and specificity.

[Complex assessment of the electrophysiologic changes in patients with left-ventricular cardiac overload].

130 healthy persons and 146 cardiac patients with left ventricular cardiac overload were examined by 4 electrophysiologic methods: corrected orthogonal electrocardiogram according to Frank, corrected orthogonal vectorcardiogram, space electrocardiogram, high-speed space electrocardiogram. 76 indices were examined. The cardiac patients were classified into two basic groups: patients with systolic overload and patients with diastolic overload.

[Complex assessment of the electrophysiological changes in patients with right-ventricular cardiac loading].

In 216 patients with right ventricular cardiac overload the changes of 76 electrophysiological indices were studied--indices of the corrected orthogonal electrocardiogram after Frank, corrected orthogonal vectorcardiogram, spatial electrocardiogram and high-speed spatial electrocardiogram. The patients with right ventricular cardiac overload are divided into two basic groups--patients with systolic and patients with diastolic overload. The indices are assessed on the basic criteria of sensitivity, specificity and realization.

[Ways of improving the diagnosis and prognosis in vasorenal hypertension].

Atherosclerosis, aorto-arteritis and fibromuscular dysplasia are the most common causes of vasorenal hypertension. Determination of plasma renin activity is a valuable diagnostic test at early stages of vasorenal hypertension. HLA studies demonstrated significantly elevated antigens B8 and B12 in patients with essential hypertension, and antigen A9 in patients with affected renal arteries.