Outcomes of COVID-19 in Patients With a History of Cancer and Comorbid Cardiovascular Disease.

Background: Cancer and cardiovascular disease (CVD) are independently associated with adverse outcomes in patients with COVID-19. However, outcomes in patients with COVID-19 with both cancer and comorbid CVD are unknown.

Methods: This retrospective study included 2,476 patients who tested positive for SARS-CoV-2 at 4 Massachusetts hospitals between March 11 and May 21, 2020.

Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma.

Background: Angiopoietins contribute to tumor angiogenesis and may be upregulated as a compensatory factor after vascular endothelial growth factor (VEGF) blockade. The authors performed a phase 2 and biomarker study to evaluate trebananib, an angiopoietin 1 and angiopoietin 2 blocking peptibody, with and without bevacizumab in patients with recurrent glioblastoma.

Methods: Forty-eight patients who had bevacizumab-naive, recurrent glioblastoma were treated with trebananib (30 mg/kg weekly) as single agent (n = 11) or combined with bevacizumab (n = 37).

Overview of chronic myeloid leukemia patients in Pakistan in the pre-imatanib era.

Objective: To study the patient characteristics of patients diagnosed with chronic myelogenous leukemia (CML) at a tertiary care cancer hospital in Pakistan.

Methods And Materials: A retrospective analysis was conducted on CML patients treated between 1996 and 2004 at Shaukat Khanum Memorial Cancer Hospital and Research Center.

Results: A total of 461 CML patient charts were reviewed.

Renal involvement in non-Hodgkin's lymphoma: the Shaukat Khanum experience.

Background: Primary lymphoma of genitourinary system is rare as these organs do not contain lymphoid tissue, however secondary involvement often occurs. The most commonly affected genitourinary organ is the kidney.

Methods: Medical records of 901 patients with documented NHL seen at Shaukat Khanum Memorial Cancer Hospital & Research Center during 1995-2003 were studied for the incidence, histopathological, clinical and radiological correlation of renal involvement in NHL.