Outcomes of Acute Promyelocytic Leukaemia in Paediatric Patients: Insights from a Low-Middle-Income Country.

Objective: To describe the prognostic variables and course of paediatric acute promyelocytic leukaemia (APL) in Pakistan.

Study Design: Cohort study. Place and Duration of the Study: Department of Paediatric Oncology, Combined Military Hospital, Rawalpindi, Pakistan, from January 2012 to December 2022.

Pediatric Acute Lymphoblastic Leukemia: Clinical Characteristics, Treatment Outcomes, and Prognostic Factors: 10 Years' Experience From a Low- and Middle-Income Country.

Purpose: Acute lymphoblastic leukemia (ALL) represents around 70% of pediatric leukemia. In high-income countries, the 5-year survival is above 90%, but survival in low- and middle-income countries is inferior. This study documents the treatment outcome and prognostic factors of pediatric ALL in Pakistan.

Measuring education sector resilience in the face of flood disasters in Pakistan: an index-based approach.

School resilience is characterized as risk management techniques to build a safe environment for students. Recognizing the need of building disaster resilience for the education sector, this study is aimed at assessing flood disaster resilience of elementary schools in four extremely vulnerable districts of Khyber Pakhtunkhwa province of Pakistan. This paper established the assessment tool by incorporating climate resilience indices and 16 tasks of the Hyogo Framework for action designed for the education sector.

Comparative anti-glycation and α-glucosidase inhibition studies of microbial transformed compounds of dydrogesterone.

Anti-glycation and α-glucosidase inhibition activities of microbial transformed compounds of dydrogesterone (1); 20R-hydroxy-9β,10αa-pregna-4,6-diene-3-one (2), 17β-hydroxy-9β,10α-androsta-4,6-diene-3-one (3) and 9β,10α-androsta-4,6-diene-3,17-dione (4) were evaluated. Compounds 1 and 4 showed potent α-glucosidase inhibitory activities, while 2 and 3 were found to be weak inhibitors, whereas anti-glycation activities of 1-4 were not observed.

Three new carbazole alkaloids and biological activities of Murraya koenigii.

Three new carbazole alkaloids, mukoenigatin (1), bikoeniquinonine (2) and murrayadinal (3), were isolated from the aerial parts of Murraya koenigii, along with mukeonine-B (4). Their molecular structures were determined on the basis of spectral analysis including UV, IR, MS, and 2D NMR spectroscopy. The antimicrobial activity of different fractions of plant extract was also determined.

Hypogylcemic activity of aqueous extract of some indigenous plants.

Pakistan is rich in medicinally important plants and has an ancient herbal treatment methods. Our work is based on the study of some indigenous plants which show inhibitory effect of glucose utilization, and are in use as hypoglycemic agent in traditional system of medicine. Gymnema sylvestre, Momordica charantia and Eugenia jumbolana have been shown to possess hypoglycemic activity of varying degree.