Publications by authors named "Shaimaa Moustafa"
Owing to their native extracellular matrix-like features, magnetic hydrogels have been proven to be promising biomaterials as tissue engineering templates In the present work, magnetic hydrogels scaffold based on chitosan, gelatin, hyaluronic acid, containing FeO as magnetic nanoparticles (IONPs) were prepared. The prepared hydrogels were loaded with ciprofloxacin hydrochloride as a model drug. The magnetic hydrogel was prepared using different volumes of chitosan, 1%, gelatin, 10%, and hyaluronic acid, 1% in glutaraldehyde as the crosslinking agent and FeO as magnetic nanoparticles.
View Article and Find Full Text PDFUpadacitinib, classified as a highly soluble drug, is commercially marketed as RINVOQ®, a modified-release formulation incorporating hydroxypropyl methylcellulose as a matrix system to target extended release throughout the gastrointestinal (GI) tract. Our study aimed to explore how drug release will occur throughout the GI tract using a plethora of in vitro and in silico tools. We built a Physiologically-Based Pharmacokinetic (PBPK) model in GastroPlus™ to predict the systemic concentrations of the drug when administered using in vitro dissolution profiles as input to drive luminal dissolution.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess the effectiveness of hybrid SPECT/CT imaging with technetium-99m methylene diphosphonate in diagnosing active unilateral condylar hyperplasia (UCH) by comparing results to histopathology.
- Twenty-four patients with suspected UCH underwent SPECT/CT, with evaluations achieving high interobserver agreement and confirming all surgeries performed led to a UCH diagnosis.
- SPECT/CT showed slightly higher sensitivity than planar scintigraphy for UCH diagnosis, while both methods had similar specificity; quantitative metrics were less sensitive than qualitative assessments.
Background: To examine the value of speckle tracking echocardiography to detect the presence, extent and severity of coronary artery affection in patients with suspected stable angina pectoris.
Methods: Two hundred candidates with suspected stable angina pectoris and normal resting conventional echocardiography were subjected to speckle tracking echocardiography and coronary angiography. Global and segmental longitudinal peak systolic strain were assessed and were correlated to the results of coronary angiography for each patient.