Combined fractional CO laser with dimethyl sulfoxide (DMSO) 50% versus fractional CO Laser alone in the treatment of macular amyloidosis: clinical and histopathological assessment.

Background: Macular amyloidosis (MA) could be of cosmetic concern with a significant psychological impact for patients, and its treatment is challenging.

Aim Of The Work: To compare the efficacy and safety of combined fractional CO laser with dimethyl sulfoxide (DMSO) 50% versus fractional CO laser alone in the treatment of macular amyloidosis.

Patients And Methods: Twenty patients with macular amyloidosis were treated with monthly session of fractional CO laser only in one side of the lesion (area A), and fractional laser followed by application of DMSO 50% solution in the other side of the lesion (area B).

Goldilocks mastectomy; a modified technique enhancing the aesthetic outcome presented as a single center single-arm prospective cohort study.

Background: Goldilocks mastectomy represents a midway solution for breast reconstruction between flat chest and sophisticated reconstructive techniques. The literature lacks a standardization of the technique. In this study, we present a step-by-step approach with modifications in the original technique achieving better breast shape and contour within the context of standardization of the technique.

Microneedling with Topical Insulin Versus Microneedling with Non-Cross-Linked Hyaluronic Acid for Atrophic Post-Acne Scars: A Split-Face Study.

Introduction: Post-acne scars are a prevalent cosmetic complaint that usually require multi-modality treatment to achieve accepted results.

Objectives: The target of this research was to evaluate and compare the efficacy and safety of microneedling with topical insulin versus microneedling with non-cross-linked hyaluronic acid in atrophic post-acne scar treatment.

Methods: The current comparative split-face research included 30 patients with atrophic facial acne scars.

Influence of titanium and titanium-zirconium alloy as implant materials on implant stability of maxillary implant retained overdenture: a randomized clinical trial.

Background: Long-term success of implant restoration depends on many factors one of them is the sufficient implant stability which is lowered in compromised bone density sites such as the maxilla as it is categorized as type III & IV bone, so searching for a new innovation and updates in implant material and features is very mandatory. So, the aim of this study was to compare between two implant materials (roxolid and traditional titanium) on the primary and secondary stability of implant retained maxillary overdenture.

Methods: Eighteen completely edentulous patients were selected.

Exploring the potential of Aspergillus wentii: secondary metabolites and biological properties.

Fungi are of considerable importance due to their capacity to biosynthesize various secondary metabolites with bioactive properties that draw high attention in new drug discovery with beneficial uses for improving human well-being and life quality. Aspergillus genus members are widespread and cosmopolitan species with varying economic significance in the fields of industry, medicine, and agriculture. Its species are renowned for their biosynthesis of secondary metabolites, characterized by both potent biological activity and structural novelty, making them a substantial reservoir for the development of new pharmaceuticals.

Accuracy and surface roughness of Co-Cr partial denture frameworks with different digital fabrication methods.

Statement Of Problem: Traditional removable partial denture (RPD) manufacture is being phased out in favor of computer-aided design and computer-aided manufacturing (CAD-CAM) techniques and rapid prototyping (RP), which provide more efficient methods of producing RPD frameworks. However, studies comparing the accuracy and surface roughness of these approaches on RPD frameworks are still scarce.

Purpose: The purpose of this in vitro study was to evaluate the accuracy and surface roughness of class I cobalt chromium (Co-Cr) removable partial denture frameworks digitally constructed using 2 different CAD-CAM technologies: direct milling (DM) and selective laser melting (SLM).

Design of new Mcl-1 inhibitors for cancer using fragments hybridization, molecular docking, and molecular dynamics studies.

Apoptosis is a critical process that regulates cell survival and death and plays an essential role in cancer development. The Bcl-2 protein family, including myeloid leukemia 1 (Mcl-1), is a key regulator of the intrinsic apoptosis pathway, and its overexpression in many human cancers has prompted efforts to develop Mcl-1 inhibitors as potential anticancer agents. In this study, we aimed to design new Mcl-1 inhibitors using various computational techniques.

Marine-Derived Compounds for CDK5 Inhibition in Cancer: Integrating Multi-Stage Virtual Screening, MM/GBSA Analysis and Molecular Dynamics Investigations.

Cyclin-dependent kinase 5 (CDK5) plays a crucial role in various biological processes, including immune response, insulin secretion regulation, apoptosis, DNA (deoxyribonucleic acid) damage response, epithelial-mesenchymal transition (EMT), cell migration and invasion, angiogenesis, and myogenesis. Overactivation of CDK5 is associated with the initiation and progression of cancer. Inhibiting CDK5 has shown potential in suppressing cancer development.

Modulation of NRF2/KEAP1-Mediated Oxidative Stress for Cancer Treatment by Natural Products Using Pharmacophore-Based Screening, Molecular Docking, and Molecular Dynamics Studies.

Oxidative stress plays a significant role in the development of cancer. Inhibiting the protein-protein interaction (PPI) between Keap1 and Nrf2 offers a promising strategy to activate the Nrf2 antioxidant pathway, which is normally suppressed by the binding of Keap1 to Nrf2. This study aimed to identify natural compounds capable of targeting the kelch domain of KEAP1 using structure-based drug design methods.

Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance of .

Marine-derived fungi are renowned as a source of astonishingly significant and synthetically appealing metabolites that are proven as new lead chemicals for chemical, pharmaceutical, and agricultural fields. is a saprotrophic, ubiquitous, and halophilic fungus that is commonly found in different marine ecosystems. This fungus can cause aspergillosis in sea fan corals leading to sea fan mortality with subsequent changes in coral community structure.

Benzophenones-natural metabolites with great Hopes in drug discovery: structures, occurrence, bioactivities, and biosynthesis.

Fungi have protruded with enormous development in the repository of drug discovery, making them some of the most attractive sources for the synthesis of bio-significant and structural novel metabolites. Benzophenones are structurally unique metabolites with phenol/carbonyl/phenol frameworks, that are separated from microbial and plant sources. They have drawn considerable interest from researchers due to their versatile building blocks and diversified bio-activities.

Ethnomedicinal uses, phytochemistry, and pharmacological relevance of Justicia procumbens (Oriental Water Willow) - A promising traditional plant.

Ethnopharmacological Relevance: Justicia procumbens L. (JP) (Oriental Water Willow, Shrimp plant, Acanthaceae) is a herbaceous plant that is commonly found in India, Taiwan, Australia, Southern China, Vietnam, and Korea. The plant has been primarily used to treat fever, asthma, edema, cough, jaundice, urinary tract infection, and sore throat, as well as for snake bites and as a fish-killer.

Optimizing the performance of Au/Ni/TiONTs photoanodes for photoelectrochemical water splitting.

Water splitting using photoelectrochemical (PEC) techniques is thought to be a potential method for creating green hydrogen as a sustainable energy source. How to create extremely effective electrode materials is a pressing concern in this area. In this work, a series of Ni/TiO anodized nanotubes (NTs) and Au/Ni/TiONTs photoanodes were prepared by electrodeposition cyclic voltammetry and UV-photoreduction, respectively.

The Impact of Social Loafing on Turnover Intention for Tourism Employees Post COVID-19: The Mediating Role of Mental Health.

The COVID-19 pandemic has led to widespread changes in the way that people work, including an increase in remote work and changes in group dynamics. Social loafing, the phenomenon of reduced individual effort in group settings, has been widely studied in the literature. However, less is known about the potential impacts of social loafing on mental health and turnover intention in this relationship.

Genus -A Wealthy Treasure: Secondary Metabolites, Synthesis, Biosynthesis, and Bioactivities.

Marine sponges are multicellular and primitive animals that potentially represent a wealthy source of novel drugs. The genus (family Axinellidae) is renowned to produce various metabolites with various structural characteristics and bioactivities, including nitrogen-containing terpenoids, alkaloids, and sterols. The current work provides an up-to-date literature survey and comprehensive insight into the reported metabolites from the members of this genus, as well as their sources, biosynthesis, syntheses, and biological activities whenever available.

Broadband Photon Harvesting in Organic Photovoltaic Devices Induced by Large-Area Nanogrooved Templates.

Thin-film organic photovoltaic (OPV) devices represent an attractive alternative to conventional silicon solar cells due to their lightweight, flexibility, and low cost. However, the relatively low optical absorption of the OPV active layers still represents an open issue in view of efficient devices that cannot be addressed by adopting conventional light coupling strategies derived from thick PV absorbers. The light coupling to thin-film solar cells can be boosted by nanostructuring the device interfaces at the subwavelength scale.

Controllable Fabrication of Zn Self-Doped TiO Tubular Nanocomposite for Highly Efficient Water Treatment.

Tailoring high-efficiency photocatalytic composites for various implementations is a major research topic. 1D TNTs-based nanomaterials show promise as a photocatalyst for the remediation of organic pigments in an aqueous solution. Despite this, TiO (TNTs) is only photoactive in the UV range due to its inherent restriction on absorption of light in the UV range.

Acaricidal Activity of Tea Tree and Lemon Oil Nanoemulsions against .

Tick infestation is a serious problem in many countries since it has an impact on the health of animals used for food production and pets, and frequently affects humans. Therefore, the present study aimed to investigate the acaricidal effects of nanoemulsions of essential oils of (tea tree, TT) and (lemon oil, CL) against the different stages (adult, eggs, and larvae) of deltamethrin-resistant ticks. Three forms of these oils were tested: pure oils, nanoemulsions, and a binary combination.

Evaluation of the Accuracy and Adaptation of BioHPP Removable Partial Denture Frameworks Constructed by Milling vs the Pressing Technique.

Purpose: To evaluate the accuracy and adaptation of BioHPP removable partial denture frameworks constructed from milling vs the pressing technique.

Materials And Methods: This in vitro study was applied on an educational maxillary stone model with bilateral bounded saddles. Two different manufacturing techniques were used, and thus two groups were defined: (1) the pressed group, in which 20 BioHPP frameworks were constructed by milling a castable resin that was pressed into BioHPP using the lost wax technique; and (2) the milled group, in which 20 BioHPP frameworks were constructed directly by milling the BioHPP blanks.

The Nexus between Green Perceived Quality, Green Satisfaction, Green Trust, and Customers' Green Behavioral Intentions in Eco-Friendly Hotels: A Structural Equation Modeling Approach.

With the growing awareness of the climate change effects, hotel customers progressively intend to favor green products and services that minimize adverse environmental effects. The key factors affecting customers' green behavioral intentions in the hospitality industry context are still under research. Accordingly, this study primarily aims at empirically investigating the nexus between green perceived quality (GPQ), green satisfaction (GS), green trust (GT), and customers' green behavioral intentions (CGBIs) in a sample of five-star eco-friendly hotels in Egypt.

Advances in Fungal Phenaloenones-Natural Metabolites with Great Promise: Biosynthesis, Bioactivities, and an In Silico Evaluation of Their Potential as Human Glucose Transporter 1 Inhibitors.

Phenaloenones are structurally unique aromatic polyketides that have been reported in both microbial and plant sources. They possess a hydroxy perinaphthenone three-fused-ring system and exhibit diverse bioactivities, such as cytotoxic, antimicrobial, antioxidant, and anti-HIV properties, and tyrosinase, α-glucosidase, lipase, AchE (acetylcholinesterase), indoleamine 2,3-dioxygenase 1, angiotensin-I-converting enzyme, and tyrosine phosphatase inhibition. Moreover, they have a rich nucleophilic nucleus that has inspired many chemists and biologists to synthesize more of these related derivatives.

Enhanced and tunable femtosecond nonlinear optical properties of pure and nickel-doped zinc oxide films.

The nonlinear optical properties of pure ZnO and Ni-doped ZnO thin films are explored using the Z-scan technique at different input laser intensities and an excitation wavelength of 750 nm by 100 fs laser pulses. The pure ZnO and Ni-doped ZnO thin films were prepared by radio frequency magnetron sputtering at room temperature. A scanning electron microscope equipped with energy-dispersive x-ray spectroscopy was used to measure the thickness and composition of the thin films, while a UV-visible spectrophotometer was used to measure the linear optical properties.

: Metabolites, Bioactivities, Biosynthesis, and Biotechnological Potential.

Fungus continues to attract great attention as a promising pool of biometabolites. Wilh (Aspergillaceae) has established its capacity to biosynthesize a myriad of metabolites belonging to different chemical classes, such as isocoumarins, pyrazines, sterols, indole alkaloids, diketopiperazines, polyketides, peptides, quinones, polyketides, and sesquiterpenoids, revealing various bioactivities that are antimicrobial, cytotoxic, antiviral, anti-inflammatory, insecticidal, and neuroprotective. Additionally, produces a variety of enzymes that could have variable industrial and biotechnological applications.

Modeling the relationship between perceived service quality, tourist satisfaction, and tourists' behavioral intentions amid COVID-19 pandemic: Evidence of yoga tourists' perspectives.

Purpose: This study aims to investigate the impact of perceived service quality (PSQ) on tourist satisfaction and behavioral intentions and explore the potential mediating role of tourist satisfaction in the relationship between service quality and behavioral intentions in the yoga tourism context during the COVID-19 pandemic. Further, this is to examine to what extent yoga tourist satisfaction directly affects their behavioral intentions.

Design/methodology/approach: Based on a review of literature, the study proposes a conceptual model to test four hypothesized relationships among the constructs of perceived service quality, tourist satisfaction, and behavioral intentions.