Assessment of serum levels of ischemia modified albumin and interleukin-17 in children with atopic dermatitis.

Background: Atopic dermatitis (AD) is the most prevalent chronic inflammatory skin disease in childhood. Interleukin 17 (IL17) is one of the pro-inflammatory cytokines that has an important role in the pathogenesis of many skin diseases including AD. Ischemia modified albumin (IMA) is an indicator of oxidative stress, inflammation and ischemia.

Systemic Sarcoidosis with Psoriasiform Plaques and Patchy Nonscarring Alopecia.

Cutaneous sarcoidosis occurs in about one-quarter of patients with systemic disease and presents with either specific or nonspecific signs. Psoriasiform sarcoidosis is an uncommon presentation. Herein, study authors report a rare case of systemic sarcoidosis that presented with psoriasiform plaques and patchy alopecia.

Self-practice among patients with psoriasis: University hospital experience.

Objectives: This study aimed to assess the self-care practices of patients with psoriasis and factors affecting them.

Methods: A cross-sectional study was conducted on 110 adult patients with confirmed diagnosis of psoriasis. Each patient underwent a personal structured interview with the physician using two predetermined questionnaires, one for assessing self-care practices and another for evaluating patients' knowledge of their disease and sociodemographic and clinical features.

IFN-α and TNF-α serum levels and their association with disease severity in Egyptian children and adults with alopecia areata.

Background: Alopecia areata (AA) is an autoimmune skin disease characterized by abnormal levels of several cytokines, such as interferon alpha (IFN-α) and tumor necrosis factor-alpha (TNF-α), which are T-helper type 1 cytokines that have important roles in the pathogenesis of AA. The aim of our study was to correlate circulating IFN-α and TNF-α levels with disease severity, activity, and clinical type in patients with AA and to evaluate the relationship between the two cytokines.

Methods: We investigated serum IFN-α and TNF-α levels in 72 patients with AA (35 children and 35 adults) and 75 healthy control individuals (34 children and 41 adults) using the enzyme-linked immunosorbent assay (ELISA) technique.

Evaluation of daily avanafil efficacy in improving the endothelial function in Egyptian males with erectile dysfunction.

Avanafil is a highly selective and potent oral phosphodiesterase type 5 inhibitor. However, its impact on the soluble markers of endothelial function has not been investigated yet. This study was conducted to assess the effect of daily avanafil on the endothelial markers' serum level and erectile function in patients with erectile dysfunction.

Differential Modulation of Autophagy Contributes to the Protective Effects of Resveratrol and Co-Enzyme Q10 in Photoaged Mice.

Background: In photoaging, the accumulation of ultraviolet (UV)-induced oxidative damage leads to the characteristic hallmarks of aging. Here arises the importance of autophagy as a cellular degradation process that cleans the cells of defective or aged organelles and macromolecules, thus maintaining cellular homeostasis. In spite of this, the exact impact of autophagy in photoaging is still elusive.