Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion.

Aims: Ran GTPase is involved in nucleocytoplasmic shuttling of proteins and is overexpressed in several cancers. The expression of Ran in malignant melanoma (MM) and its functional activity have not been described and were investigated in this study.

Methods: The prognostic value of Ran expression was tested in a series of 185 primary cutaneous MM cases using immunohistochemistry.