Publications by authors named "Shaimaa Abdelmegid"

Brucellosis is a disease caused by the () species. It is a zoonotic disease that affects farm animals and causes economic losses in many countries worldwide. has the ability to persist in the environment and infect the host at low doses.

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Bovine mastitis remains a primary focus of dairy cattle disease research due to its considerable negative economic impact on the dairy industry. Subclinical mastitis (SCM), commonly caused by , lacks overt clinical signs and the diagnosis is based on bacteriological culture and somatic cell counts of milk, both of which have limitations. The main objective of this study was to identify, characterize and quantify the differential abundance of milk whey proteins from cows with SCM compared to whey from healthy cows.

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This dataset is associated with our research article 'Identification of host-defence related proteins using label-free quantitative proteomic analysis of milk whey from cows with Subclinical mastitis' published in International Journal of Molecular Sciences. Milk samples were collected from cows suffering from -associated subclinical mastitis and the proteins abundance were identified in comparison with samples collected from the control cows using liquid chromatography-mass spectrometry (LC-MS)-based label free proteomics analysis. Following the MS measurements, the raw spectra were processed using MaxQuant-Andromeda software and the protein identification was carried out through a search against Uniprot FASTA files of the reference proteome.

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is the most common contagious pathogen associated with bovine subclinical mastitis. Current diagnosis of mastitis is based on bacteriological culture of milk samples and somatic cell counts, which lack either sensitivity or specificity. Identification of milk proteins that contribute to host defense and their variable responses to pathogenic stimuli would enable the characterization of putative biomarkers of subclinical mastitis.

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