Publications by authors named "Shailja Pandya"
Front Cell Dev Biol
November 2020
Article Synopsis
- Aquamin, a natural multi-mineral product rich in calcium and magnesium, was studied to see if it could improve the colonic barrier in patients with ulcerative colitis (UC) by utilizing colonoid cultures from their biopsies.
- The study involved incubating these colonoids with or without Aquamin for two weeks, analyzing changes in barrier proteins and structure using advanced microscopy and proteomic techniques.
- Results showed some positive effects, including increased expression of differentiation-related proteins and tight junctions, as well as improved structural features, suggesting that Aquamin may enhance barrier function in UC-affected tissue.
Article Synopsis
- The study aimed to evaluate the effects of calcium and a multi-mineral product called Aquamin on the growth and differentiation of colonoid cultures from normal human colon tissue.
- Researchers maintained colonoid cultures in low-calcium and higher calcium conditions, analyzing growth, morphology, and protein expression after two weeks.
- Results showed that normal colonoids naturally differentiated even without calcium supplementation, while both calcium alone and Aquamin enhanced proteins related to tissue integrity, but had minimal additional effects on cell growth and differentiation.
