Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus.

Context: Lipotoxicity (increased tissue fat content) has been implicated in the development of muscle insulin resistance and type 2 diabetes mellitus (T2DM).

Objective: The aim was to study the effect of pioglitazone on intramyocellular fat metabolism.

Research Design: Twenty-four T2DM subjects (glycosylated hemoglobin = 8.