Molecular mechanisms of neurofilament alterations and its application in assessing neurodegenerative disorders.

Neurofilaments are intermediate filaments present in neurons. These provide structural support and maintain the size and shape of the neurons. Dysregulation, mutation, and aggregation of neurofilaments raise the levels of these proteins in the blood and cerebrospinal fluid (CSF), which are characteristic features of axonal damage and certain rare neurological diseases, such as Giant Axonal Neuropathy and Charcot-Mare-Tooth disease.

Assessing Breast Cancer through Tumor Microenvironment Mapping of Collagen and Other Biomolecule Spectral Fingerprints─A Review.

Breast cancer is a major challenge in the field of oncology, with around 2.3 million cases and around 670,000 deaths globally based on the GLOBOCAN 2022 data. Despite having advanced technologies, breast cancer remains the major type of cancer among women.

Label-free visualization of unfolding and crosslinking mediated protein aggregation in nonenzymatically glycated proteins.

Nonenzymatic glycation (NEG) unfolds and crosslinks proteins, resulting in aggregation. Label-free evaluation of such structural changes, without disturbing molecular integrity, would be beneficial for understanding the fundamental mechanisms of protein aggregation. The current study demonstrates the assessment of NEG-induced protein aggregation by combining autofluorescence (AF) spectroscopy and imaging.

Assessment of Microgap and Bacterial Leakage of Two Types of Internal Implant-Abutment Union.

Objective: The current research was done to assess microbial seepage of two types of internal implant-abutment connections.

Materials And Methods: Twenty dental implants are categorized into two groups. Group A fixtures with an internal hexagonal geometry and group B fixtures with a tri-lobe internal connection.

Augmenting the quality and storage stability of soymilk by incorporation of untreated and ozonated oat 1,4-β-D-glucan.

The study aimed to improve the quality and storage stability of novel plant-based soymilk with the incorporation of untreated (UtβG) and modified oat derived 1,4-β-D-glucan (OzβG) at varying concentrations (0, 1, and 2 % labelled as S, S and S). The treated soymilk was characterized for physical, chemical, nutritional, rheological, particle size, zeta potential, sensory and storage stability characteristics. The results revealed that 1, 4-β-D-glucan incorporation increased the acidity (0.

Taylor-Gorilla troops optimized deep learning network for surface roughness estimation.

In order to guarantee the desired quality of machined products, a reliable surface roughness assessment is essential. Using a surface profile metre with a contact stylus, which can produce accurate measurements of surface profiles, is the most popular technique for determining the surface roughness of machined items. One of the limitations of this technique is the work piece surface degradation brought on by mechanical contact between the stylus and the surface.

A comprehensive review of protein misfolding disorders, underlying mechanism, clinical diagnosis, and therapeutic strategies.

Introduction: Proteins are the most common biological macromolecules in living system and are building blocks of life. They are extremely dynamic in structure and functions. Due to several modifications, proteins undergo misfolding, leading to aggregation and thereby developing neurodegenerative and systemic diseases.

Synthesis and assessment of anticholinesterase and antioxidant properties of triazineamide derivatives.

Cholinesterase inhibitors and radical scavengers have been recognized as powerful symptomatic anti-Alzheimer's disease agents. Hence, the present study aimed to develop new triazineamides as potent anticholinesterase and antioxidant agents. Triazineamide () derivatives were synthesized using cyanuric chloride via nucleophilic substitution followed by condensation.

Comparative Evaluation of Efficacy of Bioactive Glass, Tricalcium Phosphate, and Ozone Remineralizing Agents on Artificial Carious Lesion.

Objectives: Evaluation of efficacy of bioactive glass (BAG), tricalcium phosphate, and ozone remineralizing agents on artificial carious lesion.

Materials And Methods: Freshly extracted 48 human premolar teeth were included for this study. Remineralization of demineralized teeth was done with respective remineralizing agents (Group A - calcium sodium phosphosilicate [BAG], Group B - tricalcium phosphate [Clinpro Tooth Crème], Group C - ozone remineralizing agents, and control group: Group D - deionized water) three times a day for 12 days for 4 min.

Nanoformulations - Insights Towards Characterization Techniques.

Background: Drug-loaded novel nanoformulations are gaining importance due to their versatile properties compared to conventional pharmaceutical formulations. Nanomaterials, apart from their multifactorial benefits, have a wider scope in the prevention, treatment, and diagnosis of cancer. Understanding the chemistry of drug-loaded nano-formulations to elicit its behaviour both at molecular and systemic levels is critical in the present scenario.

Construction Building Materials as a Potential for Structural Supercapacitor Applications.

Emerging demands to achieve zero carbon emissions and develop renewable energy resources necessitate the development of appropriate energy storage systems. To achieve this, several alternatives to conventional energy storage devices, such as Li-ion batteries or capacitors to more sustainable and scalable energy storage systems, are being explored. Supercapacitors, possess unique characteristics that include high power, long life, and environmental-friendly design.

Current trends in the preparation, characterization and applications of oat starch - A review.

Worldwide consumption of oats is gaining popularity due to its composition and multifunctional benefits of individual components. Oat starch being the major component accounts up to 60% of the dry weight of kernel, possess small granule size and high lipid content. Properties of starch substantially affect the quality of the product.

Date-Leaf Carbon Particles for Green Enhanced Oil Recovery.

Green enhanced oil recovery (GEOR) is an environmentally friendly enhanced oil recovery (EOR) process involving the injection of green fluids to improve macroscopic and microscopic sweep efficiencies while boosting tertiary oil production. Carbon nanomaterials such as graphene, carbon nanotube (CNT), and carbon dots have gained interest for their superior ability to increase oil recovery. These particles have been successfully tested in EOR, although they are expensive and do not extend to GEOR.

Conductive polymer layered semiconductor for degradation of triclopyr acid and 2,4-dichlorophenoxyacetic acid from aqueous stream using coalesce adsorption-photocatalysis technique.

Polyaniline supported titanium dioxide nanoparticles (PTs) were fabricated using chemical oxidative aniline polymerization in the presence of titanium dioxide with ammonium peroxydisulfate as an oxidant. The synthesized PTs were thoroughly characterized for their morphological and functional features. PTs were employed for the photodegradation of acidic herbicides; 2,4-dichlorophenoxyacetic acid (2,4-D) and triclopyr acid (TCP).

Synthesis of N-Substituted Pyrrolidine Derivatives Bearing 1,2,4- triazole Ring.

Background: 1,2,4-triazoles scaffolds display significant biological activities due to hydrogen bonding, solubility, dipole character, and rigidity.

Objective: The core motif of 1,2,4-triazoles plays a vital role in clinical drugs such as Rizatriptan (antimigraine), Ribavirin (antiviral), anastrozole (anticancer), etizolam (anxiolytic), estazolam (anticonvulsant), alprazolam (anti-hypnotic), letrozole (aromatase inhibitor), loreclezole (anticonvulsant), trazadone (antidepressant) etc. Methods: Epoxide ring opening of tert-butyl 6-oxa-3-azabicyclo [3.

Recent Advances in Processing and Applications of Heterobimetallic Oxide Thin Films by Aerosol-Assisted Chemical Vapor Deposition.

The fabrication of smart, efficient, and innovative devices critically needs highly refined thin-film nanomaterials; therefore, facile, scalable, and economical methods of thin films production are highly sought-after for the sustainable growth of the hi-tech industry. The chemical vapor deposition (CVD) technique is widely implemented at the industrial level due to its versatile features. However, common issues with a precursor, such as reduced volatility and thermal stability, restrict the use of CVD to produce novel and unique materials.

Titanium dioxide based nanocomposites - Current trends and emerging strategies for the photocatalytic degradation of ruinous environmental pollutants.

Many ruinous pollutants are omnipresent in the environment and among them; pesticides are xenobiotic and pose to be a bio-recalcitrance. Their detrimental ecological and environmental impacts attract attention of environmental excerpts and the surge of stringent regulations have endows the need of a technically feasible treatment. This critical review emphasizes about the occurrence, abundance and fate of structurally distinct pesticides in different environment.

Preparation, Characterization, and Evaluation of the Anticorrosion Performance of Submicron/Nanocarbon from Jute Sticks.

Jute stick, one of the most commonly and abundantly available agricultural waste product, was converted to a value-added submicron/nano jute carbon by using pyrolysis and high-energy ball milling techniques. The submicron/nano jute carbon was characterized using FE-SEM, TEM, EDS, XRD, XPS and Raman spectroscopy. The anticorrosive performance of the submicron/nano jute carbon was investigated through electrochemical impedance spectroscopy (EIS), potentiodynamic polarization (PDP) and salt spray techniques, on mild steel plates coated with a mixture of epoxy resin and the submicron/nano jute carbon.

Tailor-made design, fabrication and validation of SrO doped nanostructured ZTA ceramic Femoral head - Acetabular socket liner assembly.

An established commercial grade SrO doped ZTA composition has been considered to design, fabrication through uniaxial pressing followed by sintering and polishing, validation of dimension, 3D surface profile, 3D microstructure, and compressive load bearing capacity of femoral head - acetabular socket liner prototypes for the hip prosthesis. While design and dimensions are concerned, both the steel (HRC60) molds were designed and machined to achieve precious dimensions of femoral head (FH; OD - 30 ± 0.01 mm) and acetabular socket liner (ASL; ID - 30.

Characterization, Processing, and Application of Heavy Fuel Oil Ash, an Industrial Waste Material - A Review.

Heavy fuel oil ash (HFOA) is generated as an industrial waste material during the combustion of heavy fuel oil in power/desalination plants. With increasing energy demands, a significant volume of HFOA is generated. It is generally disposed of in landfills, causing environmental pollution, as it contains several toxic elements.

Intraoperative Neurophysiological Monitoring During Trigeminal Schwannoma Surgery.

Surgical manipulation during skull base surgeries places various cranial nerves (CN) at risk, including the nerves innervating the extraocular muscles. It could be very challenging for the surgeon to identify these cranial nerves due to the distortion of the normal anatomy by the tumors. Despite the recent advancement in technology, surgeries involving the third, fourth, fifth, and sixth cranial nerves still carry a risk of temporary or permanent paralysis of the muscles supplied by these cranial nerves.

Bilateral Oval and Round Window Atresia on CT Temporal Bone: A Rare Anomaly Clinically Mimicking Otosclerosis in an Adult.

We present a rare adult case of bilateral oval and round window atresia. Clinical and audiologic findings were suggestive of otosclerosis. High resolution CT Temporal bones showed unequivocal findings of bilateral oval and round window atresia.

Can Preoperative Ultrasonography and MRI Replace Sentinel Lymph Node Biopsy in Management of Axilla in Early Breast Cancer-a Prospective Study from a Tertiary Cancer Center.

Although SLNB is a less invasive procedure in detecting axillary lymph node metastases(ALNM) in early breast cancer; still, it carries some complications like lymphedema and in addition, performing SLNB requires surgical skills, technical knowledge, presence of facility like preoperative sentinel lymphoscintigraphy, and availability of hand-held gamma probe for intraoperative assessment. We calculated the relative diagnostic strength of preoperative axillary USG and MRI and compared with of SLNB for detection of ALNM in early breast cancer and assessed whether MRI and USG could accurately predict axillary LN status, potentially replacing SLNB. We evaluated 40 cases of clinically node-negative early breast cancer with preoperative axillary USG and MRI and subsequently subjected to SLNB.

Stenotrophomonas skull base osteomyelitis presenting as necrotizing otitis externa: Unmasking by CT and MRI-case report and review.

Necrotizing or malignant otitis externa in patients presenting with mild clinical findings can pose as a tip of the iceberg; computed tomography (CT) and/or magnetic resonance imaging (MRI) unveils the clinical-imaging discrepancy and unmasks the presence of skull-base osteomyelitis (SBO). is the most common causative pathogen of SBO, followed by fungal and other rare bacterial organisms. This report presents a rare case in an elderly diabetic patient, where the pathogen was isolated.