Publications by authors named "Shai S Klaitman"
Background: Congenital Insensitivity to Pain with Anhidrosis (CIPA) is a rare hereditary neuropathy caused by NTRK1 gene mutations, predisposing patients to recurrent infections and chronic wounds. Long-term studies on microbial and clinical outcomes in CIPA are limited. This study presents analysis of infection patterns, antibiotic resistance, and clinical outcomes in CIPA patients.
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- The BRD4-NUT fusion, caused by the t(15:19) translocation, is a key driver of NUT carcinoma (NC), a rare and aggressive solid tumor, and this study explores potential targeted treatments through genomic profiling of advanced cancer cases.
- Among 31 solid tumor cases with the BRD4-NUT translocation, only 16% were initially diagnosed as NC; the rest had different diagnoses, primarily including non-small cell lung cancer (NSCLC) types, and the tumors showed low mutational burden.
- Notably, some patients treated with immune checkpoint inhibitors experienced unexpected responses, which may be explained by the strong predicted affinity of the BRD4-NUT fusion peptide to
Adolescent injuries and fatalities constitute a world health concern and present a major public health burden. Of all childhood injuries in Israel 61.8% occur during road traffic crashes.
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