Multicomponent Synthesis of -Benzyl Dithiocarbamates from -Quinone Methides and Their Biological Evaluation for the Treatment of Alzheimer's Disease.

Multicomponent synthesis of biologically relevant -benzyl dithiocarbamates from -quinone methides, amines, and carbon disulfide are described under catalyst and additive-free conditions. The reactions proceeded at room temperature in a short span of time with excellent yields. One of the synthesized compounds, showed considerable acetylcholinesterase (AChE) inhibitory (51.

C -Symmetric Bissulfoximine-Based Metal Complexes: Synthesis, Characterization and Their Electrocatalytic Activity in Oxygen Reduction Reaction.

Sulfoximine-based metal complexes have gained much interest in recent years owing to their promising properties in synthetic organic chemistry. These sulfoximines have been recently introduced in the field of organometallics. However, the coordination properties of pincer sulfoximine ligands and their metal complexes have not been reported.

Controlled reduction of activated primary and secondary amides into aldehydes with diisobutylaluminum hydride.

A practical method is disclosed for the reduction of activated primary and secondary amides into aldehydes using diisobutylaluminum hydride (DIBAL-H) in toluene. A wide range of aryl and alkyl -Boc, -diBoc and -tosyl amides were converted into the corresponding aldehydes in good to excellent yields. Reduction susceptible functional groups such as nitro, cyano, alkene and alkyne groups were found to be stable.

Diversification of α-ketoamides via transamidation reactions with alkyl and benzyl amines at room temperature.

A wide range of N-tosyl α-ketoamides underwent transamidation with various alkyl amines in the absence of a catalyst, base, or additive. On the other hand, transamidation in N-Boc α-ketoamides was achieved in the presence of CsCO. The reactions proceeded at room temperature and provided good to excellent yields of transamidation products under the optimized conditions.

Development of Routes for the Stereoselective Preparation of β-Aryl--glycosides via -1 Aryl Enones.

A wide range of enones derived from d-glucal, d-galactal, l-rhamnal, d-rhamnal, and l-arabinal underwent Heck-coupling with various arylboronic acids bearing electron-donating and -withdrawing groups in the presence of palladium acetate and 1,10-phenanthroline. These reactions provided synthetically useful -1 aryl enones in good yields. Many sensitive functional groups as well as protecting groups present in arylboronic acids and enones, respectively, remained intact under optimized conditions.

Chemoselective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)-N Bond Cleavage under Catalyst-Free Conditions.

Conversion of a wide range of -Boc amides to aryl ketones was achieved with Grignard reagents via chemoselective C(O)-N bond cleavage. The reactions proceeded under catalyst-free conditions with different aryl, alkyl, and alkynyl Grignard reagents. α-Ketoamide was successfully converted to aryl diketones, while α,β-unsaturated amide underwent 1,4-addition followed by C(O)-N bond cleavage to provide diaryl propiophenones.

Regioselective Nitration of N-Alkyl Anilines using tert-Butyl Nitrite under Mild Condition.

Regioselective ring nitration of N-alkyl anilines is reported using tert-butyl nitrite. The reactions proceed efficiently with a wide range of substrates providing synthetically useful N-nitroso N-alkyl nitroanilines in excellent yields which can be easily converted into N-alkyl phenylenediamines and N-alkyl nitroanilines using Zn-AcOH and HCl/MeOH, respectively.

tert-Butyl nitrite mediated nitrogen transfer reactions: synthesis of benzotriazoles and azides at room temperature.

A conversion of o-phenylenediamines into benzotriazoles was achieved at room temperature using tert-butyl nitrite. The optimized conditions are also well suited for the transformation of sulfonyl and acyl hydrazines into corresponding azides. This protocol does not require any catalyst or acidic medium.

Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions.

The copper meditated N-methylation of sulfoximines using methylboronic acid is reported. The reactions provide excellent yields in a short span of time under mild conditions. The optimized conditions were also found to be suitable for the N-alkylation of sulfoximine with different alkylboronic acids.

Mononuclear [(BP)(2)MX](n+) (M = Cu(2+), Co(2+), Zn(2+); X = OH(2), Cl(-)) complexes with a new biphenyl appended N-bidentate ligand: structural, spectroscopic, solution equilibrium and ligand dynamic studies.

A new series of five-coordinate [(BP)2MX]n+ complexes, (where X = OH2, M = Zn(II) (1), Cu(II) (2); X = Cl-, M = Cu(II) (3), Co(II) (4)) with a new bidentate chelating ligand [{N,N(1,1'-biphenyl-2,2'-dimethylene)-N(2-pyridyl methyl)} amine] with a biphenyl group (BP), have been synthesized and characterized by X-ray crystal structure and combined spectroscopic methods. They display unique trigonal bipyramidal (TBP) geometry, influenced by the bidentate ligand. The Zn(II) complex 1 reveals ligand dynamics due to an atropisomeric biphenyl moiety as indicated by variable temperature (VT) proton NMR spectroscopy.

First hexanuclear copper(II) pyrophosphate through hydrolysis of phosphodiester with a dicopper complex.

Facile hydrolysis of a phosphodiester promoted by a dicopper bis(mu-hydroxo) complex containing a new biphenyl appended N-bidentate ligand led to the isolation of the first example of hexameric copper pyrophosphate through 'in situ self assembly'.