Publications by authors named "Shahrzad Soori"
Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor II and Factor V with Risk of Inhibitor Development in Patients with Severe Hemophilia A.
Cardiovasc Hematol Disord Drug Targets
August 2020
Background: About one-fourth of patients with hemophilia A (HA) develop alloantibodies against factor (F) VIII, as the main treatment challenge. Here, we assessed the relationship between interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α), FII and FV polymorphisms and risk of inhibitor formation in patients with severe HA.
Methods: We divided 39 patients with severe HA in two groups of case (n: 19) and control (n: 20).
Estimation of HIV incidence provides real-time information of HIV transmission trends for decision makers. Anti-integrase antibodies are the last ones produced during seroconversion and presence of high-avidity anti-integrase antibodies indicates the chronicity of HIV infection. This study aimed to evaluate the performance of these antibodies in discriminating of recent from non-recent HIV infection.
View Article and Find Full Text PDFBackground: Rare bleeding disorders (RBDs) are heterogeneous disorders, mostly inherited in an autosomal recessive pattern. Iran is a Mideast country with a high rate of consanguinity that has a high rate of RBDs.
Objective: In this study, we present prevalence and clinical presentation as well as management and genetic defects of Iranian patients with RBDs.
Article Synopsis
- Factor XIII deficiency (FXIIID) is a rare bleeding disorder affecting about 1 in 2 million people; its severe symptoms, like umbilical cord and brain bleeding, complicate diagnosis and treatment, especially in Iran where the deficiency rate is significantly higher.
- The study compared two methods of clot solubility testing—5M urea and monochloroacetic acid (MCA)—to improve diagnosis of FXIIID among 83 patients with normal routine coagulation tests.
- Results showed that the 5M urea method is more sensitive for detecting FXIIID, but using both methods together can help avoid misdiagnosis in a significant number of cases.
Currently, enzyme immunoassays (EIAs) are the most common immunological diagnostic methods that are used as the screening tool in HIV detection. Among all three major genes of HIV, the products of gag and env are usually used in EIAs (ELISAs and rapid tests). Hence, the presence of cross reacting antibodies against these antigens leads to the appearance of repetitive false positive results in screening tests.
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