Publications by authors named "Shahnila Qureshi"
Article Synopsis
- The study focuses on creating a chimeric protein by fusing interleukin 24 with a tumor-targeting peptide (P20) to improve cancer treatment efficacy.
- Bioinformatics tools were used to analyze the protein's structure, revealing it has a basic nature, is 175 amino acids long, and weighs 20 kDa, with high structural quality.
- Docking and simulation studies suggest that the fusion protein is stable, interacts well, and shows potential as a targeted therapy for cancer.
Fusion proteins development strategies and their role as cancer therapeutic agents.
Biotechnol Appl Biochem
February 2024
Cancer continues to be leading cause of morbidity and mortality despite decades of research and advancement in chemotherapy. Most tumors can be reduced via standard oncology treatments, such as chemotherapy, radiotherapy, and surgical resection, and they frequently recur. Significant progress has been made since targeted cancer therapy inception in creation of medications that exhibit improved tumor-selective action.
View Article and Find Full Text PDFContext: Epidermal growth factor receptor (EGFR), a member of the HER receptor family, is over expressed in various cancer cells. Using tumor-specific antibodies to deliver cytotoxic agents directly to the tumor cells is an effective treatment strategy. Targeted therapy by fusing anti-EGFR scFv with tumor-specific cytokines promises the emergence of a new era.
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