Comparative Effects of Crocin and Losartan on RAGE, TGF-β, TNF-α Gene Expression and Histopathological Changes of the Liver Tissue in Rats With Diabetes.

Background And Objectives: AGEs, via RAGE, increase the development of hyperglycemia-induced liver damage, and blocking this axis is associated with a reduction in liver disease progression. The goal of this study was to determine how crocin and losartan influenced RAGE, TNF-α and TGF-β gene expression in diabetic rats, as well as histological changes in liver tissue.

Materials And Methods: Diabetes was induced in 40 male Wistar rats using Streptozotocin (50 mg/kg, IP).

Protective Effect of Berberine Nanoparticles Against Cardiotoxic Effects of Arsenic Trioxide.

Arsenic trioxide (ATO) is a potent and highly effective chemotherapeutic agent for the treatment of acute promyelocytic leukemia. However, the clinical use of ATO is hampered by different cardiopathologic outcomes, such as arrhythmia and heart failure. Berberine has several beneficial effects because of its antioxidant activity; however, the potential cardioprotective function of this alkaloid against arsenic-induced cardiac toxicity has not been fully investigated.

Corrigendum to "Oxidative stress and apoptotic index modifications in the hippocampus of rat pups born to mothers exposed to buprenorphine during lactation" [Toxicol. Rep. 2022 Nov 19; 9: 2050-2054. doi: 10.1016/j.toxrep.2022.11.005. PMID: 36518388; PMCID: PMC9742962].

[This corrects the article DOI: 10.1016/j.toxrep.

Neuroprotective Effects of Curcumin against Chronic Chlorpyrifos- Induced Oxidative Damage in Rat Brain Tissue.

Background: Chlorpyrifos (CPF) is an organophosphate pesticide that inhibits acetylcholinesterase (AChE) activity. Investigations have also focused on its neurotoxicity, which is independent of AChE inhibition. Here, we evaluated the effect of CPF on oxidative indices in the brain tissue and explored the protective effect of curcumin (Cur) against its toxicity.

The Protective Effect of Curcumin Against Cardiotoxic Effects Induced by Chronic Exposure to Chlorpyrifos.

Aims: This study aimed to evaluate the effect of Chlorpyrifos (CPF) in rat heart tissue and the effect of Curcumin (Cur) on cardiac enzymes, oxidative indices, and histopathological changes in the cardiac tissue.

Background: CPF, the most used organophosphorus pesticide (OP), has been reported to induce cardiotoxic effects.

Objective: The cardioprotective effects of Cur against CPF-induced toxicity have not been entirely investigated till now.

Protective Effects of Curcumin and its Analogues the Nrf2 Pathway in Metabolic Syndrome.

Metabolic Syndrome (MetS) refers to a set of medical conditions including insulin resistance, central obesity, atherogenic dyslipidemia, and hypertension. Due to these dysregulations, if not treated, MetS could increase the risk of CVA, CVD, and diabetes. As described by WHO, CVD is the leading cause of mortality in the world which motivates researchers to investigate the management of its risk factors, especially MetS.

Oxidative stress and apoptotic index modifications in the hippocampus of rat pups born to mothers exposed to buprenorphine during lactation.

Background: The effect of opioids administration during lactation on nervous system has not fully understood.

Objective: The aim of this study was to evaluate the buprenorphine (BUP) impact on oxidative stress indexes and apoptotic gene expression in the hippocampus of neonates exposed to this drug through breastfeeding.

Methods: Lactating female rats were subcutaneously injected with BUP (1 or 0.

Trace Element Concentration and Cognitive Dysfunction in Elderly Residents in Birjand.

Background: Trace elements were suggested to have a main role in modulating cognitive function. However, there are several controversial findings regarding the association between serum trace element concentration and cognitive function in patients with cognitive disorders.

Methods: Thus, this study aimed to evaluate the changes in serum trace element concentrations in elderly with cognitive dysfunction versus the participants with normal cognitive function.

Evaluation effect of shiatsu technique on labor induction in post-term pregnancy.

Objectives: Labor induction in post-term pregnancy is considered as a conventional process of mothers' care. Shiatsu technique is one of the complementary methods which use for post-term pregnancy induction. Therefore, the researchers decided to examine the effect of Shiatsu technique on the induction of post-term pregnancy.