Publications by authors named "Shahira A ElBanna"
Article Synopsis
- The study focuses on the global issue of hypervirulent and carbapenem-resistant Klebsiella pneumoniae, which poses a significant public health threat, especially in low- and middle-income countries due to poor antimicrobial practices.
- Researchers sequenced 19 strains of K. pneumoniae to analyze their genetic characteristics, including resistance profiles and virulence traits, finding notable high-risk clones that carry genetic factors associated with hypervirulence.
- Results showed that all carbapenem-resistant isolates demonstrated extensive drug resistance, with the presence of multiple resistance genes, highlighting the emergence of convergent strains capable of causing severe infections.
Nanobodies in the fight against infectious diseases: repurposing nature's tiny weapons.
World J Microbiol Biotechnol
May 2024
Nanobodies are the smallest known antigen-binding molecules to date. Their small size, good tissue penetration, high stability and solubility, ease of expression, refolding ability, and negligible immunogenicity in the human body have granted them excellence over conventional antibodies. Those exceptional attributes of nanobodies make them promising candidates for various applications in biotechnology, medicine, protein engineering, structural biology, food, and agriculture.
View Article and Find Full Text PDFThis study comprehensively characterized the metabolite profiles of six lettuce varieties and established the correlation between the elucidated profiles and their antivirulence effects. A total of 195 metabolites were annotated using LC-QTOF-MS/MS metabolomics assisted by molecular networking and integrated with chemometrics. Red varieties (red longifolia and lolla rosa) demonstrated higher chlorogenic and chicoric acids suggesting their antioxidant properties.
View Article and Find Full Text PDFPolycyclic aromatic hydrocarbons, e.g., benzo[a]pyrene (BaP), are common dietary pollutants with potential carcinogenic activity, while polyphenols are potential chemopreventive antioxidants.
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- Plant extracts are being explored as alternative antimicrobial sources against resistant bacteria, using advanced techniques to analyze their chemical profiles.
- The analysis of different Brassica juncea varieties revealed varying levels of phenolics, glucosinolates, and fatty acids, with significant antibacterial potential noted in the plant extracts.
- IR variety leaves showed the strongest activity against Staphylococcus aureus, linked to reduced gene transcription for virulence factors, while specific compounds like phenolics and glucosinolates were identified as contributors to this bioactivity.
Introduction: Toxin-antitoxin (TA) systems are widespread among bacteria, archaea and fungi. They are classified into six types (I-VI) and have recently been proposed as novel drug targets.
Objectives: This study aimed to screen the pathogen , known for its alarming antimicrobial resistance, for TA systems and identified a CptBA-like type IV TA, one of the least characterized systems.
Methicillin-resistant (MRSA) strains are associated with serious complications and poor clinical outcome. In Egypt, they contribute to more than 70% of healthcare-associated infections. This study combined whole-genome sequencing, bioinformatics, and statistical analyses to identify the phylogeny, resistome, virulome and potential genotype-phenotype-clinical correlation among 18 clinical isolates of MRSA in a tertiary hospital in Cairo, Egypt.
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