Topical mycophenolate mofetil in the treatment of vitiligo: a pilot study.

Background: Vitiligo is a multifactorial disease that is characterized by circumscribed depigmented macules and patches. Autoimmune reactions may play an important role in the pathogenesis of the disease. Mycophenolate mofetil is a drug that inhibits DNA synthesis in lymphocytes and has been used in autoimmune diseases such as immunobullous skin diseases, lupus erythematosus, and autoimmune hepatitis.

Epidemiology and molecular characteristics of methicillin-resistantStaphylococcus aureus from skin and soft tissue infections in Shiraz, Iran.

Background/aim: Panton-Valentine leukocidin (PVL)-positive methicillin-resistant Staphylococcus aureus (MRSA) infections are increasing in some regions of Iran. The aim of the current study was to assess the epidemiology and molecular characteristics of S. aureus isolated from patients with skin infections in Shiraz, Iran.

Prevalence of psychological disorders in patients with alopecia areata in comparison with normal subjects.

Alopecia areata is a chronic disease with a great impact on the patient's quality of life. In this study we reviewed the frequency of psychological disorders in patients with alopecia areata in comparison to a control group. We enrolled 40 patients with alopecia areata and a 40-volunteer random age-sex matched control group.

A giant polypoid basal cell carcinoma of the lower extremity.

Less than 1% of basal cell carcinomas are giant basal cell carcinomas. Giant basal cell carcinomas are rare. They preferentially involve the trunk and are commonly associated with neglect.

Impact of psoriasis on quality of life in Iran.

Background: The Psoriasis Disability Index (PDI) questionnaire is a widely used instrument to measure psychological morbidity in plaque-type psoriasis patients.

Aims: This study aimed to validate the Persian version of the PDI and to evaluate the impact of psoriasis on quality of life (QOL).

Methods: The English language version of the PDI was translated into Persian (Iranian official language) and was used in this study.

Topical immunotherapy with diphenylcyclopropenone in vitiligo: a preliminary experience.

Background: Despite recent significant therapeutic advances, vitiligo remains a clinical conundrum. Topical immunotherapy has been extensively tested in the treatment of various dermatologic disorders, especially those believed to have an immunologic basis.

Aim: To evaluate the role of topical diphenylcyclopropenone (DPCP) in the treatment of vitiligo.

An uncontrolled, open label study of sulfasalazine in severe alopecia areata.

Background: Alopecia areata (AA) is an autoimmune disease mediated by T lymphocytes. Many treatments have been used but their results remain disappointing. There is a need to propose new therapeutic alternatives.

Analysis of survival and hospitalization time for 2057 burn patients in Shiraz, southwestern Iran.

Background: Burn injuries in Iran, like in other developing countries, are much more common than in the USA and Europe. Although there are a few articles dealing with epidemiological studies of burn injuries in Iran, investigations regarding the quality of burn care are scant. This study was undertaken to determine current survival statistics and lengths of stay in the population of burned patients treated at two university burn units in Shiraz, Iran, during four years.

Dermatology Life Quality Index (DLQI) scores in burn victims after revival.

This study aimed to evaluate reliability and validity of the Dermatology Life Quality Index (DLQI) in Iranian burned patients and to examine this question, "Does burn severity or other demographical characteristics affect the patient's perception of his or her quality of life after burn injury?" In this study, we used the Persian version of DLQI questionnaire; its reliability and validity has been confirmed earlier in vitiligo patients. The questionnaire was administered to a group of patients with burn scars after revival. The internal consistency of the questionnaire was assessed by Cronbach's alpha coefficient.

Adams-Oliver syndrome and isolated aplasia cutis congenita in two siblings.

Adams-Oliver syndrome is a rare congenital anomaly complex characterized by aplasia cutis congenita (ACC) and terminal transverse limb defects. We present a 9-year-old girl with a large, congenital scalp defect on her vertex, without underlying bone defect. Brachydactyly and syndactylia of her toes were also evident.

Acquired eyelash trichomegaly and generalized hypertrichosis associated with breast anomaly.

Acquired eyelash trichomegaly is a rare condition. We present a 23-year-old woman with acquired trichomegaly and generalized hypertrichosis from childhood. The patient also exhibited bilateral nipple retraction and unilateral left-sided accessory nipple.

Treatment of disseminated facial warts through contact immunotherapy with diphenylcyclopropenone (DPCP).

This paper highlights the effect of diphenylcyclopropenone (DPCP) sensitization on warts resistant to other treatments and is interesting in views of the fact that all the facial warts apparently responded. To analyze the efficacy and side-effects of DPCP treatment of viral warts, a prospective study was designed to follow six patients with chronic and resistant facial warts through immunotherapy sensitization with diphenylcyclopropenone for 10 weekly sessions. Patients were first sensitized with 2 percent DPCP and then followed by weekly maintenance of 0.

Three cousins with chronic foot ulcers from late-onset hereditary sensory and autonomic neuropathies type 2 (HSAN2).

The hereditary sensory and autonomic neuropathies (HSAN) are a group of rare disorders characterized by prominent sensory and autonomic neuropathy without motor involvement. We report three male cousins with chronic foot ulcers, all were affected with late-onset HSAN type 2 (HSAN2). In view of the history of consanguinity and male sex, X-linked recessive transmission was likely in our patients.

The Persian version of the Cardiff Acne Disability Index. Reliability and validity study.

Objective: The Cardiff Acne Disability Index (CADI) assesses the impact of acne on a patients life. The aim of the present study was to translate the CADI into Persian language and to validate the Persian version.

Methods: Using standard forward-backward translation, 2 bilinguals translated the CADI into Persian language.

Cleft lip and palate in southwestern Iran: an epidemiologic study of live births.

Background: Cleft lip with or without cleft palate (CL/P), is the most common congenital anomaly in the head and neck worldwide. We studied the prevalence of cleft lip (CL) and palate (CP) in Shiraz, which is located in southwestern Iran.

Methods: Data was collected from the teaching hospitals of the Shiraz University of Medical Sciences.

Topical immunotherapy of severe alopecia areata with diphenylcyclopropenone (DPCP): experience in an Iranian population.

Background: Highly variable results of topical diphenylcyclopropenone (DPCP) in the treatment of alopecia areata have been reported so far. The purposes of the present study were to evaluate the efficacy and tolerability of DPCP treatment in severe alopecia areata.

Methods: Twenty-eight patients (16 female and 12 male, 10-35 years old, mean age 25 years) with extensive alopecia areata were enrolled in an open-label clinical trial.

Ulcerated disseminated cutaneous leishmaniasis associated with vitiligo, hypothyroidism, and diabetes mellitus in a patient with Down syndrome.

We report a 35-year-old man who was referred to our dermatology department with multiple, nodular, ulcerated, and crusted lesions disseminated on the face, trunk, and extremities. He has a known diagnosis of Down syndrome. The past medical history also included vitiligo (for 20 years), hypothyroidism (for 2 years), and type-II diabetes mellitus (for 3 months).

Circumscribed scalp hair loss following multiple hair-cutter ant invasion.

A 32-year-old woman presented with an abrupt, localized loss of scalp hair that occurred on the previous day. Her nails, skin, and mucosae were normal. On the vertex of the scalp, there was a circular patch of alopecia; the hairs were broken at approximately equal lengths above the skin surface.

An unusual presentation of anetoderma: a case report.

Background: Anetoderma is a benign condition with focal loss of dermal elastic tissue resulting in localized areas of flaccid or herniated saclike skin. Currently, anetoderma is classified as either primary (idiopathic), or secondary anetoderma (which is associated with a variety of skin conditions, penicillamine use, or neonatal prematurity). Lesions appear on the upper arms, trunk, and thighs.

DLQI scores in vitiligo: reliability and validity of the Persian version.

Background: The objective of this study was to translate and to test the reliability and validity of the 10-item Dermatology Life Quality Index (DLQI) questionnaire in Iranian patients with vitiligo.

Methods: Using a standard "forward-backward" translation procedure, the English language version of the questionnaire was translated into Persian (the Iranian official language) by two bilinguals. Seventy patients with vitiligo attending the Department of Dermatology, Saadi Hospital, Shiraz, Iran, were enrolled in this study.

Severe facial dermatitis as a late complication of aesthetic rhinoplasty; a case report.

Background: Contact dermatitis, as a cutaneous complication after rhinoplasty, is of early onset, limited and transient. The cause of this dermatitis is irritant or allergic. Late onset skin complications are rare and non-inflammatory.

Pyogenic granuloma arising in port-wine stain after cryotherapy.

Pyogenic granuloma is a reactive vascular tumor that rarely arises in association with port-wine stain, either spontaneously or after trauma. A 21-year-old woman, presented here, developed a pyogenic granuloma within a facial port-wine stain after treatment with cryotherapy.