Expression of HER-2/neu in Oral Squamous Cell Carcinoma.

Background: HER-2/neu is a member of the human epidermal growth factor (HER) family of transmembrane tyrosine kinases, which is significantly associated with the pathogenesis of various cancer types. The aim was to evaluate the expression of HER-2/neu in oral squamous cell carcinoma (OSCC) as a potential biomarker to target antigens for specific immunotherapy in OSCC.

Methods: One hundred and forty histologically diagnosed OSCC cases were identified.

Is routine histological evaluation of pediatric hernial sac necessary?

Advocates of routine histological examination of hernial sac recommend it for surgical quality assurance, to report injuries to the vas deferens, and to detect occult malignant and benign diseases such as tuberculosis. However, the value of this routine examination is debated in this era of cost containment in health care. We conducted a retrospective study of our practice and reviewed the relevant literature to find any justification to continue this practice.