Publications by authors named "Shahid Naikoo H"
Article Synopsis
- Melanoma is a severe cancer with low survival rates and few treatment options; this study explores the effectiveness of 3-O-prenyl glycyrrhetinic acid (NPC-402) derived from a medicinal plant against aggressive melanoma cells.
- NPC-402 was shown to induce cell death through mechanisms involving oxidative stress, apoptosis, and autophagy, which were linked to endoplasmic reticulum stress and specific signaling pathways.
- In mouse models, NPC-402 significantly reduced tumor growth and angiogenesis without major toxicity, suggesting it may be a promising candidate for melanoma treatment.
Ultraviolet (UV) exposure to the skin causes photo-damage and acts as the primary etiological agent in photo-carcinogenesis. UV-B exposure induces cellular damage and is the major factor challenging skin homeostasis. Autophagy allows the fundamental adaptation of cells to metabolic and oxidative stress.
View Article and Find Full Text PDFTrigonelline, a naturally occurring alkaloidal agent protects ultraviolet-B (UV-B) irradiation induced apoptotic cell death in human skin fibroblasts via attenuation of oxidative stress, restoration of cellular calcium homeostasis and prevention of endoplasmic reticulum (ER) stress.
J Photochem Photobiol B
January 2020
It has been widely reported that ultraviolet-B (UV-B) radiation is the main extrinsic etiological agent that causes skin photodamage. UV-B exposure mediated photodamage (photo-aging/photo-carcinogenesis) to human skin is caused due to several physiological events at tissue, cellular and molecular levels that lead to impairment of skin function and integrity. In the present study, we investigated the protective role of Trigonelline (TG) against UV-B induced photo-damage in Human Dermal Fibroblasts (Hs68 cells) and Balb/C mice.
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