Publications by authors named "Shaheen Taj"
Article Synopsis
- - Rabies is a significant issue in India, causing about 20,000 human deaths yearly, mainly due to free-roaming and unvaccinated dogs; effective vaccination is crucial for controlling the disease.
- - A study at Madras Veterinary College found that only 40% of vaccinated dogs had protective levels of rabies antibodies, raising concerns about vaccine quality and effectiveness in preventing the disease.
- - The research also indicated that older and neutered dogs are more likely to maintain protective antibody levels, while mixed-breed dogs tend to have lower levels, highlighting potential weaknesses in rabies vaccination strategies in India.
Purpose: Immunization against rabies in humans induces protective neutralizing antibodies; however, the induction of type 1 or type 2 cytokine mediated cellular immune responses following rabies vaccination is not understood. Hence, the present study investigated cellular cytokine responses in vaccinated individuals.
Materials And Methods: The study groups included healthy rabies antigen naive controls (n=10), individuals who received intradermal primary (n=10) or booster pre-exposure vaccination (n=20) and subjects who received postexposure rabies vaccination either by intradermal (n=18) or intramuscular (n=20) routes.