Publications by authors named "Shahed Al Bounny"
Article Synopsis
- Early-life immune development is essential for long-term health, but the factors influencing postnatal immune maturation are not well understood.
- The study focused on mononuclear phagocytes in Peyer's patches, showing significant age-related changes that led to reduced T cell priming in young organisms.
- The research identified that the differentiation of follicle-associated epithelium M cells is crucial for driving the maturation of these immune cells after weaning.
Microbes colonize all body surfaces at birth and participate in the development of the immune system. In newborn mammals, the intestinal microbiota is first shaped by the dietary and immunological components of milk and then changes upon the introduction of solid food during weaning. Here, we explored the reactivity of the mouse intestinal immune system during the first weeks after birth and into adulthood.
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