Re-Cellularised Kidney Scaffold for Chikungunya Virus Propagation: A Novel Approach.

Background: Re-emerging viral attacks are catastrophic for health and economy. It is crucial to grasp the viral life cycle, replication and mutation policies and attack strategies. It is also absolute to fathom the cost-efficient antiviral remedies earliest possible.

In vitro and in vivo studies reveal α-Mangostin, a xanthonoid from Garcinia mangostana, as a promising natural antiviral compound against chikungunya virus.

Background: Chikungunya virus (CHIKV), a serious health problem in several tropical countries, is the causative agent of chikungunya fever. Approved antiviral therapies or vaccines for the treatment or prevention of CHIKV infections are not available. As diverse natural phenolic compounds have been shown to possess antiviral activities, we explored the antiviral activity of α-Mangostin, a xanthanoid, against CHIKV infection.

Fabricating a pre-vascularized large-sized metabolically-supportive scaffold using leaf.

Background: There is a significant pitfall in clinical translation of large-sized tissue-engineered grafts - a lack of vascularization. This study was carried out to find the answer in a plant leaf, as plants and animals share structural similarities.

Methods And Results: We fabricated a scaffold using leaves (10%SDS) and expanded the endothelial cells onto them.

Fabrication of aortic bioprosthesis by decellularization, fibrin glue coating and re-endothelization: a cell scaffold approach.

Aortic dysfunctions (aneurysm, aortitis) lead to the most serious conditions related to aortic wall with life-threatening complications. The most common modality of management for such conditions is replacement (diseased part) of aorta by a larger diameter stent (reconstructive vascular surgery) which in itself is a big trial. The most natural way is to use a re-endothelized scaffold.