Publications by authors named "Shahd Abu-Kamel"
Article Synopsis
- The study investigates well-differentiated low-grade lung neuroendocrine tumors (LNETs), focusing on their classification and unique molecular profiles beyond the typical and atypical categories.
- Researchers used genomic techniques to reveal three distinct regulatory subtypes of LNETs, each characterized by specific transcription factors and differentiation signals: "proneuronal," "luminal-like," and "HNF+."
- Targeting the FGFR signaling pathway in the HNF+ subtype showed promise for reducing tumor growth, highlighting potential new therapeutic approaches for treating these tumors.
We describe a protocol for H3K27ac ChIP paired-end sequencing and computational analysis of rearrangements. Our approach can be used to simultaneously map enhancers and their activity and to identify structural variations at enhancers. Since changes in enhancer activity and new enhancer translocations both play a major role in tumor initiation, progression, and response to therapy, this approach holds promise to uncover some of the mechanisms behind these processes.
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