Publications by authors named "Shahar Negev"
Article Synopsis
- Traumatic brain injury (TBI) is a leading cause of death and disability in young individuals, posing significant public health and economic issues, with current treatment options being inadequate.
- This study utilizes a rat model to investigate the disruption of the blood-brain barrier (BBB) using two assessment markers, focusing on understanding the brain dysfunction that occurs after TBI.
- The research introduced a new method for evaluating BBB permeability by comparing it to traditional neuroimaging and proved effective, revealing different patterns of BBB disruption over time, with accurate sensitivity results.
Introduction: Methemoglobinemia, characterized by the conversion of functional hemoglobin to methemoglobin, can significantly impede tissue oxygenation. Prompt diagnosis and treatment of methemoglobinemia are critical to optimizing clinical outcomes. Although the underlying etiology of methemoglobinemia is often attributed to a medication reaction or chemical exposure, its association with battlefield trauma remains underexplored.
View Article and Find Full Text PDFA healthy blood-brain barrier (BBB) shields the brain from high concentrations of blood glutamate, which can cause neurotoxicity and neurodegeneration. It is believed that traumatic brain injury (TBI) causes long-term BBB disruption, subsequently increasing brain glutamate in the blood, in addition to increased glutamate resulting from the neuronal injury. Here, we investigate the relationship between blood and brain glutamate levels in the context of BBB permeability.
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