Development and evaluation of Chrysin-Phospholipid complex loaded solid lipid nanoparticles - storage stability and in vitro anti-cancer activity.

Context: Flavonoids show promising anticancer potential but it is limited due to poor solubility.

Objective: The present investigation was to prepare Chrysin-Phospholipid complex loaded solid lipid nanoparticles (Ch-PC-SLNs) for improving its encapsulation as compared to that of Chrysin loaded SLNs (Ch-SLNs) and evaluated for potential increase in the anti-cancer activity against MCF-7 cell line.

Methods: The physiochemical characteristics and release kinetics for Ch-SLNs and Ch-PC-SLNs were evaluated and compared.

Topical Nano-emulgel for Skin Disorders: Formulation Approach and Characterization.

Backgrounds: Acne vulgaris is a common chronic skin disease that affects around 9.4% (approx. 650 million people) of the global population.