Publications by authors named "Shahab Aldin Zarei"
Pharmacol Biochem Behav
December 2024
Article Synopsis
- GABA receptors are linked to drug addiction, sleep issues, and aging, but their interrelationships are not well researched; this study focuses on how blocking these receptors influences methamphetamine (METH) reward memory in sleep-deprived rats.
- Adult and adolescent male Wistar rats underwent seven days of rapid-eye movement sleep deprivation and then were conditioned with METH before testing their memory retrieval after administering the GABA receptor agonist baclofen.
- Baclofen reduced METH reward memory retrieval in both age groups, with stronger effects seen in adolescents, and the high dose lowered GABA overexpression in adolescent rats, suggesting age and sleep deprivation play significant roles in addiction mechanisms.
