Publications by authors named "Shah Saddad Hussain"
Metachrony drives effective mucociliary transport via a calcium-dependent mechanism.
Am J Physiol Lung Cell Mol Physiol
September 2024
Article Synopsis
- The mucociliary transport apparatus plays a crucial role in lung health by using coordinated cilia movement to clear mucus and particles through a process called metachrony.
- Researchers hypothesized that disruptions in calcium signaling would hinder metachrony and reduce mucociliary transport (MCT), and they tested this using imaging techniques on human and ferret tracheae.
- Results showed that metachrony significantly enhances MCT by 48% in both species and that calcium signaling is essential for maintaining this coordinated movement.
Mucociliary clearance augmenting drugs block SARS-CoV-2 replication in human airway epithelial cells.
Javier Campos-Gómez Courtney Fernandez Petty Marina Mazur Liping Tang George M Solomon Shah Saddad Hussain
Am J Physiol Lung Cell Mol Physiol
April 2023
The coronavirus disease (COVID-19) pandemic, caused by SARS-CoV-2 coronavirus, is devastatingly impacting human health. A prominent component of COVID-19 is the infection and destruction of the ciliated respiratory cells, which perpetuates dissemination and disrupts protective mucociliary transport (MCT) function, an innate defense of the respiratory tract. Thus, drugs that augment MCT could improve the barrier function of the airway epithelium and reduce viral replication and, ultimately, COVID-19 outcomes.
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