Publications by authors named "Shah S"

Health care provider retention is important for mitigating workforce shortages in underserved areas. The National Health Service Corps (NHSC) provides loan repayment for a two or three-year service commitment from clinicians to work in underserved areas. Prior studies have mixed findings as to what influences clinician retention and have focused mainly on individual-level background characteristics.

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The outcome for children with cancer has improved significantly over the past 60 years, with more than 80% of patients today becoming 5-year survivors. Despite this progress, cancer remains the leading cause of death from disease in children in the United States and Europe, with significant short- and long-term toxicity of treatment continuing to impact most children. While the past 15 years have witnessed dramatic scientific innovation for certain cancers in adult patients, pediatric cancer treatment innovation lags increasingly behind.

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Background And Aims: Awake intubation is the preferred method for securing difficult airways. We compared intravenous (IV) propofol and dexmedetomidine for C-MAC D-blade-guided anticipated difficult nasotracheal intubation under conscious sedation.

Methods: This randomised study included 60 patients with difficult airway (El-Ganzouri Score 4-9).

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Article Synopsis
  • MEK inhibitors often lead to mucocutaneous toxicities that can interfere with cancer treatment, prompting a review of related literature to understand these side effects better.
  • The scoping review analyzed 227 relevant studies, revealing common toxicities like follicular reactions, ocular issues, dry skin, and eczema, with most cases being mild and manageable.
  • Recognizing and addressing these side effects early on is crucial to minimizing interruptions in cancer therapy.
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In the bustling metropolis of tomorrow, where pollution levels are a constant concern, a team of innovative researchers embarked on a quest to revolutionize air quality monitoring. In pursuit of this objective, this study embarked on the synthesis of indium oxide materials via a straightforward solvothermal method purposely for NO detection. Through meticulous analysis of their gas-sensing capabilities, a remarkable discovery came to light.

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Visual cortical neurons show variability in their responses to repeated presentations of a stimulus and a portion of this variability is shared across neurons. Attention may enhance visual perception by reducing shared spiking variability. However, shared variability and its attentional modulation are not consistent within or across cortical areas, and depend on additional factors such as neuronal type.

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Pain management clinics differ in treatments offered, and little evidence exists regarding which combinations of therapies result in best outcomes. This study analyzed clinical encounters and pain outcomes data for associations between treatment composition and outcomes. Retrospective observational study of 2,142 predominantly active-duty US service members referred to an interdisciplinary pain management center between 2014 and 2021.

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Article Synopsis
  • The study aims to understand heart failure (HF) characteristics and outcomes specifically in octogenarians (people aged 80 and older), as this age group is often underrepresented in research despite higher HF prevalence.
  • Analysis of data from eight randomized trials revealed that octogenarians with different types of HF (HFrEF, HFmrEF, HFpEF) tended to be more female and had more health complications, worse health status, and higher rates of hospitalization and mortality compared to younger patients.
  • The findings indicate that octogenarians receive less treatment based on guidelines, particularly certain medications, despite their poorer health and worse outcomes, suggesting a need for better management in this age group.
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Psoriasis is a chronic inflammatory disorder affecting over 100 million people, requires long-term therapy. Current treatments offer only symptomatic relief. However, phytoconstituents-based therapies like Silymarin (SLM) have shown promising effects.

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The pursuit of high-performance thermoelectric materials is of paramount importance in addressing energy sustainability and environmental concerns. Here, we explore the multifaceted impact of sulfur passivation in the matrix of tellurium nanowires (TeNWs), encompassing environmental control, thermoelectric properties, and charge carrier mobility. In this study, we present the facile production of TeNWs using an aqueous solution synthesis approach.

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  • Ischemic heart disease (IHD) is prevalent among women, with cardiovascular disease being a major health risk; many experience angina due to nonobstructive coronary arteries, classified as angina with nonobstructive coronary arteries (ANOCA).
  • The underlying causes of ischemia in ANOCA can be difficult to diagnose, leaving many women with ongoing symptoms and potential long-term health risks, while current diagnostic methods still largely focus on atherosclerosis.
  • Recent advancements in diagnostic testing for ANOCA are outlined along with a proposed diagnostic algorithm, emphasizing the importance of personalized strategies based on individual medical histories and disease likelihood, aligning with expert guidelines.
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  • Firefighting is linked to an increased risk of lung cancer, but current screening guidelines don't factor in occupational exposure.
  • A study involved 1347 firefighters undergoing low-dose CT scans, revealing that 3% had high-risk lung nodules, with most being individuals not eligible for screening.
  • The findings suggest that firefighting could independently lead to high-risk lung nodules, indicating a need to revise screening guidelines to include occupational hazards.
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Purpose: Predicting the progression of intermediate AMD (iAMD) to neovascular AMD (nAMD) will help to identify high-risk patients and improve treatment outcomes. The present study assessed whether choroidal OCT biomarkers could predict conversion to nAMD.

Methods: This retrospective study included patients with clinically stable iAMD who either converted to nAMD (C group) or did not convert (NC group) during one year of follow-up.

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Hemoglobin D variations are a group of hemoglobinopathies caused by mutations in the genes that control the synthesis of new globin chains. Hemoglobin D-Punjab is the most prevalent but frequently asymptomatic, it can occasionally cause mild to moderate hemolytic anemia, making diagnosis difficult and raising the risk of misdiagnosis. This article discusses a rare instance of a seventeen-year-old male in Sindh, Pakistan with iron deficiency anemia who was later found to have the Punjab variation of the hemoglobin D.

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Background: Patient navigation interventions (PNIs) can provide personalized support and promote appropriate coordination or continuation of health and social care services. Online PNIs have demonstrated excellent potential for improving patient knowledge, transition readiness, self-efficacy, and use of services. However, the characteristics (ie, intervention type, mode of delivery, duration, frequency, outcomes and outcome measures, underlying theories or mechanisms of change of the intervention, and impact) of existing online PNIs to support the health and social needs of individuals with illness remain unclear.

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  • A 67-year-old man experienced severe complications, including hypotension and heart issues, after receiving preoperative vancomycin for a knee surgery.
  • The report details the emergency response to his cardiovascular collapse, highlighting successful medical management leading to his full recovery.
  • This case emphasizes the risks of preoperative antibiotics and the necessity for personalized patient care to ensure safety during surgical procedures.
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Digoxin is a Na-K ATPase inhibitor commonly used to treat heart failure and atrial fibrillation. It is only approved for oral or intravenous (IV) use. There is no approved indication for intrathecal administration.

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Introduction: Recent studies have evaluated patient perception of physician attire; however, few studies have considered physician perceptions of workplace attire. This study aimed to assess current trends regarding attire preferences among surgeons.

Methods: A national, population-based survey was distributed via email and "X" (Twitter).

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Background: Considering the high prevalence of mitral regurgitation (MR) and the highly subjective, variable MR severity reporting, an automated tool that could screen patients for clinically significant MR (≥ moderate) would streamline the diagnostic/therapeutic pathways and ultimately improve patient outcomes.

Objectives: The authors aimed to develop and validate a fully automated machine learning (ML)-based echocardiography workflow for grading MR severity.

Methods: ML algorithms were trained on echocardiograms from 2 observational cohorts and validated in patients from 2 additional independent studies.

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  • - Pain is a common issue in dermatology that can impact daily activities and overall quality of life, varying in intensity from mild to severe across different skin conditions.
  • - Serious skin diseases like pemphigus vulgaris and Stevens-Johnson syndrome require a team approach to pain management, often involving pain specialists and addressing both nociceptive and neuropathic pain types.
  • - Effective pain management strategies include medications ranging from non-opioids to opioids, guided by the WHO analgesic ladder, but there is a lack of research and awareness surrounding this topic in dermatology.
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