Association of vitamin B12 mediated hyperhomocysteinemia with depression and anxiety disorder: A cross-sectional study among Bhil indigenous population of India.

Background: Indigenous populations in India are amongst the poorest and most marginalized population groups experiencing severe health deprivation.

Aim: The present study is the first study that aims to understand the association of micronutrient deficiencies (vitamin B12 and folate) and MTHFR C677T gene polymorphism with depression and generalized anxiety disorder (GAD) among the Bhil indigenous population of India.

Methods: A total of 303 participants aged 25-65 years of both sexes and unrelated up to first cousins belonging to Bhil indigenous population were recruited for the present study.