Upregulation of C-X-C chemokine receptor type 4 (CXCR4) in the breast cancer stem like cells.

Background And Objectives: Breast cancer stem like cells (CSCs) as a subset of cancer cells exhibit similar properties with normal stem cells. These cells are responsible for cancer metastasis and recurrence. Pivotal roles of CXCR4 in metastasis, chemoresistance and stemness of tumor cells have been showed previously.