The effects of metformin on the hippo pathway in the proliferation of melanoma cancer cells: a preclinical study.

YAP and TAZ, two closely related transcriptional regulators, have crucial roles in tissue repair upon injury, organ size control, and cancer treatment. Some drugs, such as metformin, that alter cell metabolism can play a role in the regulation of the Hippo pathway. The cells were treated with various concentrations of metformin, dacarbazine (IC), and both of them.

Metastatic components in colorectal cancer.

Recent experiments have shown that cells with different genetic mutations can give rise to cancer transformation, both and , supported by the crosstalk between cancer cells and stroma. The stroma and the complex set of involved cells make up the tumor microenvironment that supports the engraftment of metastatic cells. In fact, environmental factors support colorectal cancer arise by formation and maintenance of cancer stem cells (CSCs).