Publications by authors named "Shafizadeh Milad"

Article Synopsis
  • Stroke is a major global health issue, with about one-third of patients facing a second stroke, prompting this study to explore machine learning (ML) algorithms for predicting recurrent strokes.
  • The study analyzed 12 research papers involving over 24,000 individuals, revealing that ML models have a sensitivity of 71% and a specificity of 88% for predicting recurrent strokes.
  • While the results are promising, indicating that ML could help identify high-risk patients, the study highlights the need for standardized methods and further research to improve the consistency and applicability of these predictive models.
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  • This study explores the predictive value of certain radiographic features for neurologic outcomes in patients with basilar artery occlusion (BAO) who undergo endovascular therapy, as prior trials only included specific patients based on prognostic scores.
  • It analyzes data from a thrombectomy database, correlating various demographic factors and radiographic scoring systems (PCCS, BATMAN, pc-ASPECTS) with 90-day neurologic outcomes, finding that lower scores on PCCS and BATMAN were linked to worse outcomes.
  • Results showed that 21.5% of patients had a good neurologic outcome after 90 days, with significant associations found between poor outcomes and existing infarcts in specific brain
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  • Glioma is a common type of brain tumor, and a specific mutation can indicate a better chance of recovery.
  • The study used machine learning to analyze data from 22 studies involving over 5,000 patients to see how well it could predict the mutation.
  • Results showed that machine learning is quite accurate in predicting the mutation status, but more work is needed to make it even better for doctors to use in treating patients.
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Introduction: Penetrating neck trauma (PNT) due to gunshot injuries is one of the challenging conditions with the potential for both significant morbidities and mortality.

Research Question: There are significant concerns in the approach to patients with spinal gunshot injuries. Surgery indications, methods of surgery, and management of CSF leaks are the main concerns of these patients.

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Article Synopsis
  • Recurrent intracranial aneurysms pose a significant clinical challenge, and the WEB device has been identified as a promising endovascular treatment option for these complex cases.
  • A systematic review of studies evaluated the performance of the WEB device, including occlusion rates and complication rates, using data from multiple databases.
  • The analysis showed favorable outcomes, with an adequate occlusion rate of 80% and no reported periprocedural complications, indicating the WEB device's effectiveness in treating recurrent wide-neck intracranial aneurysms.
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  • Machine learning (ML) algorithms can identify unruptured intracranial aneurysms (UIA), potentially saving lives, especially in high-risk groups.
  • A systematic review and meta-analysis of 35 studies showed that ML effectively predicts the risk of cerebral aneurysm rupture, with high sensitivity and specificity rates.
  • While ML shows promise in predicting aneurysm rupture risks, further research is necessary to improve its accuracy in clinical practice.
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Objective: To compare short-term clinical and radiological outcomes and complication profiles between bilateral dual sacral-2-alar-iliac (S2AI) screw and bilateral single S2AI screw fixation techniques in patients who underwent grade 3 or 4 spinal osteotomies.

Methods: A retrospective review of 83 patients treated with bilateral dual S2AI screws and 32 patients treated with bilateral single S2AI screws was conducted between 2018 and 2020 with a minimum 1-year follow-up. Clinical and radiological outcomes of patients and incidence of perioperative complications, including rod breakage, screw dislodgment, proximal junctional kyphosis, proximal junctional failure, need for reoperation, and systemic adverse effects, were collected and statistically compared between the groups.

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Unlabelled: The application of pterional approach via the extended lateral corridor (PAVEL) for aneurysms of the distal basilar artery has been associated with significant successes. However, this approach has been rarely used to manage multiple aneurysms in patients who are not candidates for endovascular intervention.

Case Presentation: A 58-year-old male patient was referred to our neurosurgical unit with severe headache, nausea and vomiting, and neck pain.

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Background: Glioblastoma is associated with low median survival time irrespective of maximal treatment. Previous in vitro studies have revealed tumor inhibitory effect of cyclosporine A. However, whether the addition of cyclosporine could improve survival among patients with glioblastoma is unknown.

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Objective: The purpose of this study was to compare the effect of single burr hole (SBH) versus double burr hole (DBH) drainage on the recurrence rate of chronic subdural hematoma (CSDH).

Method: Forty-four patients undergoing burr hole craniostomy (BHC) between July 2022 and December 2022 were enrolled in a randomized clinical trial (RCT) comparing SBH to DBH surgeries. The primary endpoint of this study was the recurrence rate of CSDH.

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Study Design: Retrospective cohort study.

Purpose: This study aimed to investigate the cervical collar impact on the functional outcomes of patients after posterior cervical laminectomy and lateral mass screw fixation (PCLF) surgery.

Overview Of Literature: The safety and possible benefits of implementing rigid cervical collars subsequent to PCLF are insufficiently investigated.

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Article Synopsis
  • Glioblastoma (GBM) is the most prevalent brain tumor, and current treatments have low survival rates with no definitive chemotherapy options established.
  • This study investigates the effects of dimethyl fumarate (DMF) on brain injuries from surgery in 36 GBM patients, comparing a group taking DMF with a placebo group before and after surgery.
  • Although there was no significant difference in serum S100β levels post-surgery between the groups, the DMF group reported a higher performance status after surgery, suggesting potential benefits but raising questions about its effectiveness in standard GBM treatment.
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Objective: Predicting meningioma consistency with preoperative imaging is critical for surgery planning. Preoperative T1 and T2-weighted and fluid attenuated inversion recovery magnetic resonance imaging (MRI) findings of supratentorial meningioma tumors were studied and compared with intraoperative supratentorial meningioma tumor consistency based on the Cavitron ultrasound surgical aspirator (CUSA) and ZADA grading scales in this cohort to predict the tumor consistency before surgery.

Methods: MRI from 78 consecutive patients who underwent supratentorial meningioma tumor resection between 2018 and 2021 were evaluated preoperatively.

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Background: Percutaneous iliosacral screw fixation in posterior pelvic ring fractures is challenging and commonly performed under fluoroscopy or navigation techniques. This study aimed to assess the safety and efficacy of percutaneous iliosacral screw implantation under fluoroscopy guidance with only inlet and outlet views.

Methods: This retrospective study included 58 consecutive unstable posterior pelvic injury patients (36 sacral fractures and 22 sacroiliac joint disruptions) treated with percutaneous iliosacral screws between January 2015 and November 2019.

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Aim: To assess the role of topical administration of tranexamic acid (TXA) on intraoperative and postoperative blood loss of patients undergoing posterior cervical laminectomy and lateral mass screw ?xation (PCLF) compared to a control group.

Material And Methods: The data of 88 patients that underwent PCLF surgery, including 41 females and 47 males, were included in this retrospective study. Data elements including intraoperative blood loss (IBL), postoperative blood loss (PBL), amount of blood transfusion, surgical time, use of hemostatic agents, length of hospital stay, and time to return to work were extracted from medical records and compared between those who received topical TXA during surgery (irrigation of the surgical field with a solution of 3 g TXA in 100 ml normal saline) and an age- and sex-matched control group.

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Introduction And Importance: Although some immunocompetent patients have developed invasive aspergillosis, the vast majority of cases are seen in immunocompromised patients. COVID-19 infection has been proposed to cause immune dysfunction or suppression, which predisposes patients to fungal co-infections such as mucormycosis and aspergillosis.

Case Presentation: A 58-year-old woman was admitted to the hospital with confusion, dysarthria, and loss of consciousness.

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Mate preference in short-term relationships and long-term ones may depend on many physical, psychological, and socio-cultural factors. In this study, 178 students (81 females) in sports and 153 engineering students (64 females) answered the systemizing quotient (SQ) and empathizing quotient (EQ) questionnaires and had their digit ratio measured. They rated their preferred mate on 12 black-line drawing body figures varying in body mass index (BMI) and waist to hip ratio (WHR) for short-term and long-term relationships.

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Background: This study examines the changes in segmental and global cervical sagittal parameters after single-level anterior cervical discectomy and fusion (ACDF) in patients with cervical radiculopathy or myelopathy. We also investigate whether these changes have any relation with postoperative pain and functional outcome of the patients.

Methods: Sixty patients (37 females and 23 males) with a mean age of 45.

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It is about half a century since free-living amoebae were recognized as pathogenic organisms, but there is still much we should learn about these rare fatal human infectious agents. A recently introduced causative agent of granulomatous amoebic encephalitis, Balamuthia mandrillaris, has been reported in a limited number of countries around the world. A 3-year-old girl was referred to our tertiary hospital because of inability to establish a proper diagnosis.

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Background: Infections are a major concern in fixation surgeries. Most of the infections could occur in the first three months after the operation.

Case Report: We present a 45-year-old man who known case of achondroplasia who underwent craniospinal fixation and was presented to our clinic with surgical site infection after six years.

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Pioglitazone is a member of peroxisome proliferator-activated receptor gamma (PPARγ) agonists, particularly used in management of type II diabetes. However it also has effects in some dermatological disorders. The current study was designed to investigate the effects of oral administration of pioglitazone and the association of nitric oxide, in serotonin-induced scratching in mice.

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