Comparative Efficacy of Dexmedetomidine and Remifentanil in Reducing Postoperative Pain and Opioid Use: A Systematic Review.

Postoperative pain management is a critical component of patient care following surgical procedures. Opioid analgesics, particularly Remifentanil, have been traditionally used to manage pain, but these drugs come with significant risks, including opioid-induced hyperalgesia (OIH) and the potential for dependence on opioids. Dexmedetomidine, an alpha-2 adrenergic receptor agonist, is a promising non-opioid alternative.