In Vitro and Randomized Controlled Clinical Study of Natural Constituents' Anti-HPV Potential for Treatment of Plantar Warts Supported with In Silico Studies and Network Analysis.

The aim of this study is to evaluate the anti-HPV potential of a Lam seed, L. seed, and peel herbal mixture in the form of polymer film-forming systems. A clinical trial conducted in outpatient clinics showed that the most significant outcome was wart size and quantity.

Pro-Apoptotic Activity of -Obtusane against Cervical Cancer: Nano Formulation, In Silico Molecular Docking, and Pharmacological Network Analysis.

Cancer is a major disease that threatens human health all over the world. Intervention and prevention in premalignant processes are successful ways to prevent cancer from striking. On the other hand, the marine ecosystem is a treasure storehouse of promising bioactive metabolites.

New cytotoxic dammarane type saponins from Ziziphus spina-christi.

Cancer is the world's second-leading cause of death. Drug development efforts frequently focus on medicinal plants since they are a valuable source of anticancer medications. A phytochemical investigation of the edible Ziziphus spina-christi (F.

Phytochemical analysis and anti-infective potential of fungal endophytes isolated from Nigella sativa seeds.

Endophytic fungi, particularly from higher plants have proven to be a rich source of antimicrobial secondary metabolites. The purpose of this study is to examine the antimicrobial potential of three endophytic fungi Aspergillus sp. SA1, Aspergillus sp.

The anti-infective potential of the endophytic fungi associated with supported by metabolomics analysis and docking studies.

Endophytic fungi are known to be a rich source of anti-infective drugs. In our study, was investigated for fungal diversity using different media to give 11 isolates which were identified morphologically. Out of the isolated fungal strains, sp.

Bioassay-Guided Fractionation with Antimalarial and Antimicrobial Activities of .

Bioassay-guided fractionation technique of roots of led to isolation and structure elucidation of seven known compounds, including four monoterpene glycosides: lactiflorin (), paeoniflorin (), galloyl paeoniflorin (), and ()-(1,5)--pinen-10-yl -vicianoside (); two phenolics: benzoic acid () and methyl gallate (); and one sterol glycoside: -sitosterol 3---D-glucopyranoside (). The different fractions and the isolated compounds were evaluated for their antimicrobial and antimalarial activities. Fraction II and III showed antifungal activity against with IC values of 28.

Antimicrobial potentials of natural products against multidrug resistance pathogens: a comprehensive review.

Antibiotic resistance is one of the critical issues, describing a significant social health complication globally. Hence, the discovery of novel antibiotics has acquired an increased attention particularly against drug-resistant pathogens. Natural products have served as potent therapeutics against pathogenic bacteria since the glorious age of antibiotics of the mid 20th century.

The Potential of Seeds Buccal Films for Treatment of Recurrent Minor Aphthous Ulcerations in Human Volunteers.

Aphthous ulcers are very common disorders among different age groups and are very noxious and painful. The incidence of aphthous ulcer recurrence is very high and it may even last for a maximum of 6 days and usually, patients cannot stand its pain. This study aims to prepare a buccoadhesive fast dissolving film containing seed extract to treat recurrent minor aphthous ulceration (RMAU) in addition to clinical experiments on human volunteers.

Network Pharmacological Analysis of the Red Sea Sponge Extract to Reveal Anticancer Efficacy of Corresponding Loaded Niosomes.

In this study, the LC-HRMS-assisted chemical profiling of sponge led to the annotation of eleven major compounds (-). -derived crude extract (HE) was tested in vitro for its antiproliferative activity against three human cancer cell lines, Hep-G2 (human liver cancer cell line), MCF-7 (breast cancer cell line), and Caco-2 (colon cancer cell line), before and after encapsulation within niosomes. showed moderate in vitro antiproliferative activities towards the studied cell lines with IC values 18.

Mechanistic Wound Healing and Antioxidant Potential of Seeds Extract Supported by Metabolic Profiling, In Silico Network Design, Molecular Docking, and In Vivo Studies.

Moringa oleifera Lam. (Moringaceae) is an adaptable plant with promising phytoconstituents, interesting medicinal uses, and nutritional importance. Chemical profiling of M.

Antiulcer Potential of Seed Extract Supported by Metabolic Profiling and Molecular Docking.

One of the most severe human health problems is gastric ulceration. The main aim of our study is to explore the gastroprotective effect of the seeds extract (PGE). Metabolic profiling based on LC-HRMS for the extract led to the dereplication of 23 compounds (-).

Wound Healing and Antioxidant Capabilities of Fruits: In-Vitro, In-Vivo, and Molecular Modeling Study.

LC-HRMS-assisted chemical profiling of Zizyphus mauritiana fruit extract (ZFE) led to the dereplication of 28 metabolites. Furthermore, wound healing activity of ZFE in 24 adult male New Zealand Dutch strain albino rabbits was investigated in-vivo supported by histopathological investigation. Additionally, the molecular mechanism was studied through different in-vitro investigations as well as, studying both relative gene expression and relative protein expression patterns.

A randomized double blinded clinical trial to explore the clinical outcomes of vaginal isonicotinic acid hydrazide (INH) administration six hours prior to T380A intrauterine device insertion in persons delivered only by cesarean delivery.

Objective: To compare insertion pain and ease of insertion in participants with a prior caesarean delivery having copper intrauterine device (IUD) after pretreatment with isonicotinic acid hydrazide (INH) 900 mg vaginally or placebo.

Study Design: From September 2020 to September 2021, we conducted a randomized, double-blind, placebo-controlled experiment at Aswan University Hospital in Egypt with participants who were delivered solely by caesarean delivery and desired copper T380A IUD insertion. The participants were randomly assigned to either vaginal INH or placebo six hours before IUD insertion in a 1:1 ratio.

(doum)-derived extract alleviates hyperglycemia in diabetic rats: a comprehensive , and study.

In the present study, we investigated the hypoglycemic effect of different extracts ( organic and aqueous) derived from the fruits of (doum) on male streptozotocin-induced diabetic rats. Blood glucose levels as well as the relative gene expression of insulin, TNF-α, and TGF-β were determined in the pancreatic tissue of the experimental animals. Treatment of STZ-induced diabetic rats with aqueous extracts of the plant fruit over 7 weeks significantly reduced the elevated blood glucose and increased the relative expression of insulin, while the relative expression of inflammatory mediators ( TNF-α and TGF-β) was significantly reduced.

Targeting 3CLpro and SARS-CoV-2 RdRp by sp. Metabolites: A Computational Study.

Since December 2019, novel coronavirus disease 2019 (COVID-19) pandemic has caused tremendous economic loss and serious health problems worldwide. In this study, we investigated 14 natural compounds isolated from sp. via a molecular docking study, to examine their ability to act as anti-COVID-19 agents.

Cytotoxic activity of actinomycetes sp. and s sp. associated with marine sponge sp.

Cancer is a hazard life-threatening disease, which affect huge population worldwide. Marine actinomycetes are considered as promising source for potential chemotherapeutic agents. In our study, we carried out metabolic profiling for sp.

Antiulcer Potential of L. cv. Arbequina Leaf Extract Supported by Metabolic Profiling and Molecular Docking.

Gastric ulceration is among the most serious humanpublic health problems. L. cv.

Cytotoxic potential of the Red Sea sponge sp. supported by modelling and dereplication analysis.

The chemical profile of the butanol fraction of the Red Sea sponge sp. was explored using liquid chromatography coupled with high-resolution mass spectrometry and identified compounds (). Moreover, cytotoxic activities of the total extract and other fractions were examined against three cell lines HEPG2, MCF7 and CACO2, revealed the powerful effect of the total extract and the butanol fraction against the three cell lines.

Hepatitis C Virus NS3 Protease and Helicase Inhibitors from Red Sea Sponge () Species in Green Synthesized Silver Nanoparticles Assisted by in Silico Modeling and Metabolic Profiling.

Background: Hepatitis C virus (HCV) infection is a major cause of hepatic diseases all over the world. This necessitates the need to discover novel anti-HCV drugs to overcome emerging drug resistance and liver complications.

Purpose: Total extract and petroleum ether fraction of the marine sponge ( spp.

Do brain abscesses have a higher incidence of odontogenic origin than previously thought?

Objective: The aim of this study was to answer the following clinical question: "In patients admitted to a tertiary care hospital with a diagnosis of brain abscess, how common is odontogenic etiology?"

Study Design: We designed a retrospective study of patients with brain abscesses diagnosed at the Massachusetts General Hospital between 1980 and 2017. Inclusion criteria were complete medical records outlining clinical course, relevant dental history, and radiographic and microbiologic data.

Results: Of 167 intracranial abscesses, 88 (52.

Reducing Blood Loss During Abdominal Hysterectomy with Intravenous Versus Topical Tranexamic Acid: A Double-Blind Randomized Controlled Trial.

Objectives: To assess the effect of intravenous versus topical tranexamic acid in reducing intraoperative and postoperative blood loss in women with abdominal hysterectomy.

Materials And Methods: The study was a randomized double-blind placebo-controlled trial, carried out in a tertiary university hospital in Egypt, from November 2015 to October 2017. A total of 129 women undergoing abdominal hysterectomy for benign etiology were randomly assigned to three groups: Group I [43 patients received 110 ml normal saline IV just before skin in scion], Group II [43 patients received 1 g tranexamic acid in 100 ml saline IV just before skin in scion], and Group III [43 patients received 2 g topical tranexamic acid applied intra-abdominal after hysterectomy].

Natural Product Repertoire of the Genus .

Marine sponges are a very attractive and rich source in the production of novel bioactive compounds. The sponges exhibit a wide range of pharmacological activities. The genus consists of various species, such as , , , and , along with a handful of undescribed species.