Background And Objective: Muscle atrophy in end-stage renal disease (ESRD) may be due to the activation of apoptotic and proteolytic pathways. We hypothesized that activation of caspase-3 in the skeletal muscle mediates apoptosis and proteolysis during haemodialysis (HD).
Materials And Methods: Eight ESRD patients were studied before (pre-HD) and during HD and the findings were compared with those from six healthy volunteers.