A post-injury immune challenge with lipopolysaccharide following adult traumatic brain injury alters neuroinflammation and the gut microbiome acutely, but has little effect on chronic outcomes.

Patients with a traumatic brain injury (TBI) are susceptible to hospital-acquired infections, presenting a significant challenge to an already-compromised immune system. The consequences and mechanisms by which this dual insult worsens outcomes are poorly understood. This study aimed to explore how a systemic immune stimulus (lipopolysaccharide, LPS) influences outcomes following experimental TBI in young adult mice.

Tuning the Spin Transition and Carrier Type in Rare-Earth Cobaltates via Compositional Complexity.

There is growing interest in material candidates with properties that can be engineered beyond traditional design limits. Compositionally complex oxides (CCO), often called high entropy oxides, are excellent candidates, wherein a lattice site shares more than four cations, forming single-phase solid solutions with unique properties. However, the nature of compositional complexity in dictating properties remains unclear, with characteristics that are difficult to calculate from first principles.

Adsorption and migration behaviors of heavy metals (As, Cd, and Cr) in single and binary systems in typical Chinese soils.

In this study, the competitive adsorption and migration behaviors of arsenic (As), cadmium (Cd), and chromium (Cr) in typical Chinese soils were investigated. It was observed that Hainan, Shanxi, and Zhejiang Mengjiadai soils exhibited the highest adsorption capacities for As (563 μg/g), Cd (653 μg/g), and Cr (383 μg/g), respectively. Heavy metals (HMs) adsorption capacities were predicted by Extreme gradient boosting (XGBoost) models, and the Shapley additive explanation (SHAP) was employed to elucidate the effect of soil physicochemical properties on target values.

Childhood cancer presentation and initial outcomes in Ethiopia: Findings from a recently opened pediatric oncology unit.

There were no pediatric oncology centers in southwest Ethiopia prior to 2016. This study aims to describe presenting diagnoses and initial outcomes at Jimma University Medical Center (JUMC), the first pediatric oncology unit (POU) in southwest Ethiopia, provide initial insights into regional pediatric cancer epidemiology, illustrate the rapid growth of pediatric cancer services, and highlight ongoing challenges. We used a retrospective descriptive approach to assess the epidemiologic pattern and initial treatment outcomes of pediatric cancer at JUMC POU from August 2016 through December 2022.

Insights into Metabolites Profiling and Pharmacological Investigation of wall ex. Royle Stem through Experimental and Bioinformatics Techniques.

The genus is a leading source of a wide range of structurally diverse metabolites with significant pharmacological implications. The present study investigated metabolite profiling, pharmacological investigation, anticancer potential, and molecular docking analysis of the stem part of (AHS). The metabolite profiling of the AHS extract was experimentally examined using LC-MS/MS-orbitrap in both modes (ESI/ESI) and GC-MS in EI mode.

Activated eosinophils in early life impair lung development and promote long-term lung damage.

Exaggeration of type 2 immune responses promotes lung inflammation and altered lung development; however, eosinophils, despite expansion in the postnatal lung, have not been specifically assessed in the context of neonatal lung disease. Furthermore, early life factors including prematurity and respiratory infection predispose infants to chronic obstructive pulmonary disease later in life. To assess eosinophils in the developing lung and how they may contribute to chronic lung disease, we generated mice harboring eosinophil-specific deletion of the negative regulatory enzyme SH2 domain-containing inositol 5' phosphatase-1.

Anxiety, a significant risk factor for coronary artery disease: what is the best index.

Background: Coronary artery disease (CAD) is known as the leading cause of disability and death globally. Anxiety disorders are also recognized as common types of mental disorders that substantially impact global health. Iran ranks among the countries with a high incidence of CAD and anxiety disorders.

Modelling lung infection with Klebsiella pneumoniae after murine traumatic brain injury.

Pneumonia is a common comorbidity in patients with severe traumatic brain injury (TBI), and is associated with increased morbidity and mortality. In this study, we established a model of intratracheal Klebsiella pneumoniae administration in young adult male and female mice, at 4 days following an experimental TBI, to investigate how K. pneumoniae infection influences acute post-TBI outcomes.

Insights into oxidation of pentachlorophenol (PCP) by low-dose ferrate(VI) catalyzed with α-FeO nanoparticles.

In this study, the catalytic performance of α-FeO nanoparticles (nα-FeO) in the low-dose ferrate (Fe(VI)) system was systematically studied through the degradation of pentachlorophenol (PCP). Based on the established quadratic functions between nα-FeO amount and observed pseudo first-order rate constant (k), two linear correlation equations were offered to predict the optimum catalyst dosage and the maximum k at an applied Fe(VI) amount. Moreover, characterization and cycling experiments showed that nα-FeO has good stability and recyclability.

Modulating chronic outcomes after pediatric traumatic brain injury: Distinct effects of social and environmental enrichment.

Impairments in social and cognitive function are a common consequence of pediatric traumatic brain injury (TBI). Rehabilitation has the potential to promote optimal behavioral recovery. Here, we evaluated whether an enhanced social and/or cognitive environment could improve long-term outcomes in a preclinical model of pediatric TBI.

Gene Ablation Does Not Influence Seizure Susceptibility, Tissue Damage, or Cellular Inflammation after Murine Pediatric Traumatic Brain Injury.

Pediatric traumatic brain injury (TBI) is a major public health issue, and a risk factor for the development of post-traumatic epilepsy that may profoundly impact the quality of life for survivors. As the majority of neurotrauma research is focused on injury to the adult brain, our understanding of the developing brain's response to TBI remains incomplete. Neuroinflammation is an influential pathophysiological mechanism in TBI, and is thought to increase neuronal hyperexcitability, rendering the brain more susceptible to the onset of seizures and/or epileptogenesis.

Localized, time-dependent responses of rat cranial bone to repeated mild traumatic brain injuries.

While it is well-established that bone responds dynamically to mechanical loading, the effects of mild traumatic brain injury (mTBI) on cranial bone composition are unclear. We hypothesized that repeated mTBI (rmTBI) would change the microstructure of cranial bones, without gross skull fractures. To address this, young adult female Piebald Viral Glaxo rats received sham, 1×, 2× or 3× closed-head mTBIs delivered at 24 h intervals, using a weight-drop device custom-built for reproducible impact.

Lumbar discal cyst and post-operative discal pseudocyst: a case series.

Four cases of lumbar cyst (2 discal cysts and 2 post-operative discal pseudocysts) who presented predominantly with features of sciatica without any motor, sensory or sphincteric disturbances. The patients were treated conservatively, and the management was aimed to avert any untoward surgical intervention taking into consideration patient safety and care. Two had previous lumbar decompressive discectomy.

Pyrochlore Compounds From Atomistic Simulations.

Pyrochlore compounds ( O) have a large applicability in various branches of science and technology. These materials are considered for use as effective ionic conductors for solid state batteries or as matrices for immobilization of actinide elements, amongst many other applications. In this contribution we discuss the simulation-based effort made in the Institute of Energy and Climate Research at Forschungszentrum Jülich and partner institutions regarding reliable computation of properties of pyrochlore and defect fluorite compounds.

Missed cervical spine subluxation leading to bilateral facet dislocation with severe deformity requiring 360 fixation.

A 41 year-old male that presented after a fall downstairs and the initial imaging was misinterpreted, missing a subtle abnormality, C5/6 subluxation. The patient presented later with neck pain and further imaging demonstrated bilateral facet dislocation with severe deformity requiring 360 spinal fixation.

Chordomas and chondrosarcomas of the skull base: treatment and outcome analysis in a consecutive case series of 24 patients.

Background: We present our 9-year consecutive case series of skull base chordomas and chondrosarcomas from a UK tertiary referral centre, discussing treatments offered and outcomes. This was carried out to improve understanding around current treatment and to better inform the management of future patients.

Methods: Consecutive case series over a 9-year period (2007-2016).

Results of a pre-implementation analysis of Ethiopia's National Pediatric Cancer Registry.

In Ethiopia, cancer accounts for about 5.8% of total national mortality, with an estimated annual incidence of cancer of approximately 60,960 cases and an annual mortality of over 44,000 persons. This is likely an underestimation.

Training pediatric hematologist/oncologists for capacity building in Ethiopia.

Purpose: A considerable barrier to global pediatric oncology efforts has been the scarcity and even absence of trained professionals in many low- and middle-income countries, where the majority of children with cancer reside. In 2013, no dedicated pediatric hematology-oncology (PHO) programs existed in Ethiopia despite the estimated annual incidence of 6000-12000 cases. The Aslan Project initiative was established to fill this gap in order to improve pediatric cancer care in Ethiopia.

Development and Validation of a New Domestic Software for Dose Assessment during Normal and Accident Conditions in Nuclear Power Plants (NPPS).

In this research, a comprehensive code called KIANA is developed based on the Gaussian plume model to simulate and predict the radiological consequences received through all the possible, reasonable, probable, and standard exposure pathways for NPPs and chemical facilities. To validate the KIANA code, a case study is modeled for Bushehr Nuclear Power Plant Unit One (BNPP-1), and the KIANA code results are compared with the results of the Final Safety Analysis Report (FSAR-2017) data of BNPP-1. To assess the performance of the KIANA code, the total dose due to the airborne pathway in accident conditions including small break LOCA (SBLOCA), large break LOCA (LBLOCA), and equivalent exposure dose for the thyroid gland of a group of infants and children age 1 to 8 y at BNPP-1, are investigated.

Design and development of a comprehensive program for the assessment and analysis of environmental effects due to the release of radioactive materials from the stack of nuclear installations: A case study in Bushehr nuclear power plant.

The current investigation presents a comprehensive program called KIANA to assess and analyze the environmental effects due to the release of radioactive materials from the stack of nuclear installations. Bushehr Nuclear Power Plant Unit One (BNPP-1) is modeled using the KIANA software and the release of radioactive materials from the BNPP-1 stack on the members of the public through the airborne pathway is evaluated during normal operation as well as in the accident conditions including Design Basis Accidents (DBA) and Beyond Design Basis Accidents (BDBA). To verify and validate the KIANA software, the results of the KIANA are compared with the results of DOZA_M, ESTE, PC-CREAM 98, RECASS Express, and the values of the total effective dose monitored by the local detectors of BNPP-1.

Shigella sonnei: virulence and antibiotic resistance.

Shigella sonnei is the emerging pathogen globally, as it is the second common infectious species of shigellosis (bloody diarrhoea) in low- and middle-income countries (LMICs) and the leading one in developed world. The multifactorial processes and novel mechanisms have been identified in S. sonnei, that are collectively playing apart a substantial role in increasing its prevalence, while replacing the S.

Long-term stability of retreated defective restorations in patients with vertical food impaction.

Background: Vertical food impaction (VFI) is a common complaint among patients receiving interproximal restorations. However, there is a gap in the literature regarding outcomes of treating defective restorations with VFI. This study sought to determine 10-year stability of retreated defective restorations in patients diagnosed with VFI.

Photodegradation of polychlorinated diphenyl sulfides (PCDPSs) under simulated solar light irradiation: Kinetics, mechanism, and density functional theory calculations.

The direct photolysis of 25 individual polychlorinated diphenyl sulfides (PCDPSs) substituted with 1-7 chlorine atoms was investigated using a 500-W Xe lamp. Photolysis of PCDPSs followed pseudo-first-order kinetics, with the higher chlorinated diphenyl sulfides generally degrading faster than the lower chlorinated congeners. A quantitative structure-activity relationship model to predict the photolysis rates of PCDPSs was developed using 16 fundamental quantum chemical descriptors.

THE VALIDATION OF COMPREHENSIVE SOFTWARE FOR THE ASSESSMENT OF RADIOLOGICAL IMPACTS ON HUMANS THROUGH BENCHMARK ANALYSIS WITH RADIOLOGICAL CODES.

In this paper, a novel domestic code called KIANA was developed for the assessment of radiological impacts on the population in normal and accident conditions including design basis accident (DBA) and beyond DBA (BDBA) for the nuclear power plants. The validation process of the KIANA code was performed using the results of the DOZA_M radiological code, whose results are presented in the Final Safety Analysis Report (FSAR) of the Bushehr Nuclear Power Plant Unit One (BNPP-1). The calculations of KIANA are performed based on the Gaussian diffusion model.