Protective effects of glycerol and xylitol in keratinocytes exposed to hyperosmotic stress.

Our goal was to study whether glycerol and xylitol provide protection against osmotic stress in keratinocytes. The experiments were performed on HaCaT keratinocytes. Hyperosmotic stress was induced by the addition of sorbitol (450, 500 and 600 mOsm).

Beyond the physico-chemical barrier: Glycerol and xylitol markedly yet differentially alter gene expression profiles and modify signalling pathways in human epidermal keratinocytes.

Polyols (e.g. glycerol, xylitol) are implicated as moisturizers of the skin and other epithelial tissues.

Effects of Locally Applied Glycerol and Xylitol on the Hydration, Barrier Function and Morphological Parameters of the Skin.

Glycerol and xylitol hydrate the skin and improve its barrier function over a short period. We studied the effects of glycerol and xylitol on the physiological properties and morphology of the skin after longer-term application. Twelve volunteers with dry skin were examined.

Antiirritant properties of polyols and amino acids.

Background: Antiirritants are used in cosmetic products to prevent or to treat skin irritations that arise during daily life. Data were published earlier on the efficacy of the best-known humectant, glycerol, in reducing irritation.

Objective: The aim of the present study was to examine the effects of different polyols (including glycerol, xylitol, and mannitol) and the amino acids taurine and glycine on sodium lauryl sulfate (SLS)-induced skin irritation.

Canine meibometry: establishing baseline values for meibomian gland secretions in dogs.

Meibomian lipid secretions are essential in preventing tear evaporation. Disorders of the meibomian glands may therefore play an important role in the pathogenesis of some forms of keratoconjunctivitis sicca (KCS). Until now, meibomian lipid secretions have never been quantitatively evaluated in dogs.

The influence of eyelid temperature on the delivery of meibomian oil.

The aim of this study is to establish the effect of heating and cooling of the eyelid on the delivery of oil from the meibomian glands, as indicated by the extent of re-establishment of the reservoir of meibomian oil on the human eyelid margin, resulting from 10 conscious blinks, following pre-cleaning by a hexane swab. A standard handling sequence was followed. Step 1.

A novel in vivo model in guinea pigs for dry skin syndrome.

BACKGROUND/AIMS: The lack of a suitable, validated animal model for the comparison of the pharmacological effectiveness of known and potential moisturizers in the treatment of "dry skin syndrome" led us to develop such an in vivo model. METHODS: "Dry skin syndrome" was induced in guinea pigs by daily application of 2% sodium lauryl sulphate (SLS) in deionized water on one of the two shaved flanks for three consecutive days. After ascertaining skin dryness, that side was treated with an agent for 6 days.