Publications by authors named "Shabnam Aghababaie"
Article Synopsis
- Spray-freeze drying (SFD) is a method used to create stable pharmaceutical powders, and this study examined how various sugars and polyols affect the stability and spray-ability of Immunoglobulin G (IgG).
- The research involved measuring soluble aggregates and analyzing the structural integrity of IgG using techniques like size-exclusion chromatography and spectroscopy over a period of 3 months at elevated temperatures.
- Results indicated that Trehalose and its combinations with Lactose and Mannitol effectively stabilized IgG with minimal aggregation, while Mannitol provided good aerodynamic properties but led to higher protein aggregation, suggesting the need for different excipients for optimal respiratory delivery of IgG.
We aimed to prepare spray-freeze-dried powder of IgG considering physicochemical stability and aerodynamic aspects. Spray-freeze drying (SFD) exposes proteins to various stresses which should be compensated by suitable stabilizers. The competence of cyclodextrins (CDs), namely beta-cyclodextrin (βCD) and hydroxypropyl βCD (HPβCD), at very low concentrations, was investigated in the presence of separate mannitol- and trehalose-based formulations.
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