Reduction of Extramedullary Complications in Patients With Acute Myeloid Leukemia/Myelodysplastic Syndrome Treated With Azacitidine.

The distinction between myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) often relies on an arbitrary marrow blast cutoff of 30% in pediatrics and 20% in adults. There is little data about the treatment of children with extramedullary myeloid malignancy that has features of both, MDS and AML. Herein, we report for the first time 2 patients MDS/AML (1 with Shwachman-Diamond syndrome and 1 with idiopathic MDS and monosomy 7) who presented with extramedullary complications, received treatment with azacitidine, achieved complete remission and subsequently underwent hematopoietic stem cell transplantation.

Reanalysing genomic data by normalized coverage values uncovers CNVs in bone marrow failure gene panels.

Inherited bone marrow failure syndromes (IBMFSs) are genetically heterogeneous disorders with cytopenia. Many IBMFSs also feature physical malformations and an increased risk of cancer. Point mutations can be identified in about half of patients.

ERCC6L2-associated inherited bone marrow failure syndrome.

Background: ERCC6L2-associated disorder has recently been described and only five patients were reported so far. The described phenotype included bone marrow, cerebral, and craniofacial abnormalities. The aim of this study was to further define the genetic and phenotypic spectrum of the disorder by summarizing the five published cases and an additional case that we identified through whole-exome sequencing performed at the University of Toronto.

Dependence of the value of the atomic magnetic moment of d metals on the chemical structure of nanoforms.

The X-ray photoelectron spectroscopy was used for studying the dependence of the 3d-metal spin state in nanoforms on the nanoform chemical structure. For studying the nanoform chemical structure a model developed by us was used, which allowed to find out the interrelation between the parameters of the X-ray electron 3s spectra of transition metals and the number of uncompensated electrons in metal atoms. It is shown that the nanoform chemical structure is determined by the methods used for their preparation and by the nanoreactor form.

Investigations of porous silicon with deposited 3D-metals by Auger- and ultrasoft X-ray emission spectroscopy.

Nanocomposites based on porous silicon (Por-Si) with 3d-metals incorporated into pores can be used as magnetics. Por-Si layers were obtained by anodic etching of n-type silicon (100) with the use of HF solution in alcohol. Fe, Co, Ni galvanic deposition in por-Si was made from aqueous solutions of corresponding sulphates.

[Morphological and genetic characteristics of the malarial mosquito Anopheles beklemishevi (Diptera, Culicidae)].

The paper presents morphological and genetic data on the malarial mosquito Anopheles beklemishevi Stegnii et Kabanova, 1976. It also provides morphological accounts of eggs, age stage IV larvae, and, firstly, pupae and imagoes. The paper considers it possible to use cytogenetic and molecular markers to identify An.