Publications by authors named "Shabana S Insaf"
Article Synopsis
- Lactoquinomycin and related compounds are identified as selective inhibitors of the AKT kinase, which is important in cancer cell signaling.
- Synthetic versions of these compounds were created, helping to outline their minimal active features and initial structure-activity relationships (SAR).
- The compounds show effectiveness against human tumor cells with active AKT and support a proposed mechanism where they work by bioreductive alkylation.
